Protein Alignment Pak3 and lats2

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001116779.1
• Gene: lats2 / 567674
• ZFINID: ZDB-GENE-050119-6
• Length: 1140
• Species: Danio rerio
• Alignment Length: 605
• Identity: 134/605 - (22%)
• Similarity: 220/605 - (36%)
• Gaps: 189/605 - (31%)

  Fly   103 IENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEV 167
            :.:..|..|.|:.....::....:|.|.:.|||.|..::.....|..|..       |:.::..:
Zfish   440 VPSRTNSFNNHQKVTVRQTLPPTASVAGKPESSLGPPNTITAVTSPPIQP-------PVKSIRVM 497

  Fly   168 FKELKTNL-------------EHRETLKAAPQE------------PPPVPPK------------- 194
            ..|.||.:             |.:::|...|.|            |||..||
Zfish   498 RPEPKTAVGPCHPGWLSAQSPEAQDSLGYIPDENFTLEPSQEHRCPPPPYPKTLLVSGSGPEPAS 562

  Fly   195 ---------------------------------------KSPHTIPPKPQIKPKPRVTQKFSRTS 220
                                                   |....:..|.||:..|...:|.:|..
Zfish   563 LEPVAMSGLQDVSATGRTIQSSSVGKQEEPIFKDKVKMGKGEKAVKDKKQIQTSPVPVRKNARDE 627

  Fly   221 DIRR---------------DEDSDN-----QHKINTDTIIIKPAVGAQDAGADDNPDETILRRSK 265
            :.|.               ::..:|     |.|:|....:.:.   ...||..:...|.:.:...
Zfish   628 EKRESRIKSYSPFAFKFYMEQHVENVMKTYQQKLNRRMQLEQE---MSKAGLSEAEQEQMRKMLY 689

  Fly   266 EK-------RAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKT 323
            :|       |..|.|..::|:::.:                |.||.|.|.:...:...:..|:||
Zfish   690 QKESNYNRLRRAKMDKSMFVKIKTL----------------GIGAFGEVCLTRKVDTGALYAMKT 738

  Fly   324 I---DMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTET- 384
            :   |:.|::....:..|..:|.:.:::.:|...  |..:..|.|:.||:|:.||.:..::...
Zfish   739 LRKKDVLNRNQVAHVKAERDILAEADNEWVVRLY--YSFQDRDNLYFVMDYIPGGDMMSLLIRMG 801

  Fly   385 VMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIE--------- 440
            |..|........|...||..:|..|.||||||.||:|:.:||.:|:||||.|....
Zfish   802 VFPEVLARFYVAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQ 866

  Fly   441 ------------------------GD-----EKRQT----------MVGTPYWMAPEVVTRKKYG 466
                                    ||     |:|.|          :||||.::||||:.||.|.
Zfish   867 KGNHIRQDSMEPSDSWDDVSNCRCGDRLMTLEQRATRQHQRCLAHSLVGTPNYIAPEVLLRKGYT 931

  Fly   467 KKVDIWSIGIMAIEMIEGQPPYLYETPLRA-LYLIAANGRPDIKSWDKLSPNLQDFLDR-CLQVE 529
            :..|.||:|::..||:.||||:|..||..| |.:|.......:....||||...|.:.: |...|
Zfish   932 QLCDWWSVGVILFEMLVGQPPFLAPTPTEAQLKVINWENTLQVPPQVKLSPEAVDIIGQLCCSAE 996

  Fly   530 VDRRA--TADELLSHPFLND 547
             :|..  .|.|:.:|||.::
Zfish   997 -ERLGGNGAGEIKAHPFFSE 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	89/312 (29%)
		S_TKc	293..545	CDD:214567	89/307 (29%)
lats2	NP_001116779.1	UBA_LATS2	105..145	CDD:270581
		Med15	175..>635	CDD:255446	32/201 (16%)
		PKc_like	706..1088	CDD:304357	91/329 (28%)
		S_TKc	708..1013	CDD:214567	90/323 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910