DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and slkb

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001315314.1	Gene:	slkb / 562769	ZFINID:	ZDB-GENE-030131-1684	Length:	969	Species:	Danio rerio

Alignment Length:	312	Identity:	115/312 - (36%)
Similarity:	170/312 - (54%)	Gaps:	21/312 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 ILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTI 324
            |.:...||:.::.|        .:....:|.|.::...|:|.||.|.||.|.:.|.....|.|.|
Zfish     9 IFKLGIEKKKKQYD--------HVHRDTNPEEIWEIVGELGDGAFGKVFKAQNKQTGIFAAAKVI 65

  Fly   325 DMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVV--TETVMK 387
            |.|.:...:..:.||.:|...:|.|:|..|||:..  |.:||:::|:..||.:..|:  .|..:.
Zfish    66 DTKTEDELEDYMVEIDILASCDHHNIVKLLDAFYF--ESKLWILIEFCAGGAVDAVMLELERPLT 128

  Fly   388 ERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA-NIEGDEKRQTMVGT 451
            |.||..||::||.|:.:||...:||||:|:.|:||.:||.||:.|||..| |.:..::|.:.:||
Zfish   129 EPQIRVVCKQTLDALLYLHDNKVIHRDLKAGNILLTLDGDVKLADFGVSAKNTKTVQRRDSFIGT 193

  Fly   452 PYWMAPEVV---TRK--KYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSW 511
            |||||||||   |.|  .|..|.||||:||..||:.:.:||.....|:|.|..||....|.:...
Zfish   194 PYWMAPEVVMCETSKDRPYDYKADIWSLGITLIELAQIEPPNHEMNPMRVLLKIAKAEPPTLLQP 258

  Fly   512 DKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLN---DCSEVKALVPNIKA 560
            .|.||..:|||...|:..||.|.:..:||.|||::   |...::.|:...||
Zfish   259 SKWSPEFRDFLKHALEKNVDNRWSTAQLLQHPFVSTVTDSRPLRELIAEAKA 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	106/264 (40%)
		S_TKc	293..545	CDD:214567	104/259 (40%)
slkb	NP_001315314.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910