DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Stk39

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_062235.1	Gene:	Stk39 / 54348	RGDID:	621643	Length:	553	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	122/416 - (29%)
Similarity:	185/416 - (44%)	Gaps:	101/416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 AAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGA 247
            ||...|.|.|...:|....|.|...|                                 .||..|
  Rat    29 AATSAPAPAPAPAAPAAPAPAPAAAP---------------------------------APAPAA 60

  Fly   248 QDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAAD 312
            |..|                             ..||     |:.|:..:.:|.||:.:|..|..
  Rat    61 QAVG-----------------------------WPIC-----RDAYELQEVIGSGATAVVQAALC 91

  Fly   313 LQNESQVAVKTIDM-KNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGP 376
            ...:.:||:|.|:: |.|:|.|.:|.||:.:...:|.|:|.:..::::  :|:||:||:.:.||.
  Rat    92 KPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVV--KDELWLVMKLLSGGS 154

  Fly   377 LTDVV---------TETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTD 432
            :.|::         ...|::|..||.:.:|.|..:.:||..|.||||:|:.|:|||.||||::.|
  Rat   155 MLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIAD 219

  Fly   433 FGFCA------NIEGDEKRQTMVGTPYWMAPEVVTR-KKYGKKVDIWSIGIMAIEMIEGQPPYLY 490
            ||..|      ::..::.|:|.||||.||||||:.: :.|..|.|:||.||.|||:..|..||..
  Rat   220 FGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHK 284

  Fly   491 ETPLRALYLIAANGRP-------DIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDC 548
            ..|::.|.|...|..|       |.:...|...:.:..|..|||.:..:|.||.|||...|....
  Rat   285 YPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKA 349

  Fly   549 SEVKALV-------PNI-KAAKKVLR 566
            ...:.|:       |:| :.||||.|
  Rat   350 KNREYLIEKLLTRTPDIAQRAKKVRR 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	97/280 (35%)
		S_TKc	293..545	CDD:214567	96/275 (35%)
Stk39	NP_062235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		9/58 (16%)
		STKc_OSR1_SPAK	70..346	CDD:270787	96/277 (35%)
		S_TKc	72..346	CDD:214567	96/275 (35%)
		Interaction with RELT. /evidence=ECO:0000250\|UniProtKB:Q9Z1W9	319..544		19/57 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	369..375		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..431		5/6 (83%)
		Caspase cleavage related site	396..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910