DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Slk

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_006231620.1	Gene:	Slk / 54308	RGDID:	3780	Length:	1234	Species:	Rattus norvegicus

Alignment Length:	311	Identity:	116/311 - (37%)
Similarity:	174/311 - (55%)	Gaps:	20/311 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 ILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTI 324
            |.:...||:.::     |..::...|   |.|.::...|:|.||.|.|:.|.:.:.....|.|.|
  Rat     9 IFKLGSEKKKKQ-----YEHVKRDLN---PEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVI 65

  Fly   325 DMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVV--TETVMK 387
            |.|::...:..:.||.:|...:|.|:|..|||:..  |:.||:::|:..||.:..|:  .|..:.
  Rat    66 DTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYY--ENNLWILIEFCAGGAVDAVMLELERPLT 128

  Fly   388 ERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA-NIEGDEKRQTMVGT 451
            |.||..||::||.|:::||...|||||:|:.|:|..:||.:|:.|||..| |....::|.:.:||
  Rat   129 ESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGT 193

  Fly   452 PYWMAPEVV---TRK--KYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSW 511
            |||||||||   |.|  .|..|.|:||:||..|||.|.:||:....|:|.|..||.:..|.:...
  Rat   194 PYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQP 258

  Fly   512 DKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSE--VKALVPNIKA 560
            .:.|.|.:|||.:||:..||.|.|..:||.|||:...|.  |:.|:...||
  Rat   259 SRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKA 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	105/264 (40%)
		S_TKc	293..545	CDD:214567	103/259 (40%)
Slk	XP_006231620.1	STKc_SLK	28..309	CDD:270811	110/285 (39%)
		S_TKc	34..292	CDD:214567	103/259 (40%)
		PKK	851..989	CDD:289257
		PKK	1019..1159	CDD:289257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910