DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and TAOK3

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001333416.1	Gene:	TAOK3 / 51347	HGNCID:	18133	Length:	907	Species:	Homo sapiens

Alignment Length:	296	Identity:	101/296 - (34%)
Similarity:	158/296 - (53%)	Gaps:	15/296 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 ELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDL---ILTEIR 340
            |:..:...|||.|.:....|:|.|:.|.|:.|.:......||:|.:....:.:.:.   ||.|::
Human    10 EIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVK 74

  Fly   341 VLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDV--VTETVMKERQIACVCRETLYAIS 403
            .|:...|.|.:.:...||  .|...|:||||..|. .:|:  |.:..::|.:||.:....|:.::
Human    75 FLRQLKHPNTIEYKGCYL--KEHTAWLVMEYCLGS-ASDLLEVHKKPLQEVEIAAITHGALHGLA 136

  Fly   404 FLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVV---TRKKY 465
            :||:..:||||||:.|:||...|.||:.|||..:..   ....:.|||||||||||:   ...:|
Human   137 YLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMA---SPANSFVGTPYWMAPEVILAMDEGQY 198

  Fly   466 GKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEV 530
            ..||||||:||..||:.|.:||......:.|||.||.|..|.::| ::.:.:.:.|:|.|||...
Human   199 DGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQS-NEWTDSFRRFVDYCLQKIP 262

  Fly   531 DRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLR 566
            ..|.|:.|||.|.|:.....::.|:..|:..|..:|
Human   263 QERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVR 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	94/264 (36%)
		S_TKc	293..545	CDD:214567	91/259 (35%)
TAOK3	NP_001333416.1	STKc_TAO3	2..314	CDD:270803	101/296 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910