Protein Alignment Pak3 and PAK3

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001121640.1
• Gene: PAK3 / 5063
• HGNCID: 8592
• Length: 580
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 231/595 - (38%)
• Similarity: 323/595 - (54%)
• Gaps: 130/595 - (21%)

  Fly    19 EIGAPTNFQRHFHVSRNQETGDL------------------------------------EGLPAP 47
            ||..|::|:...||..:..||:.                                    ||:|..
Human    69 EISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQ 133

  Fly    48 WVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKN 111
            |.||: .|.||:.||.|||.|....:|:|                       :|||..|...|.:
Human   134 WARLLQTSNITKLEQKKNPQAVLDVLKFY-----------------------DSKETVNNQKYMS 175

  Fly   112 KHKSQDPEKSDDDGSSTATETESSSGCGSSAG--NSNSSSINDSSQQSTVPLDALEEVFKELKTN 174
                                  .:||..|:.|  .::.||...:|:....|..:.||
Human   176 ----------------------FTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEE-------- 210

  Fly   175 LEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTI 239
             :..|..:....|||||              |.|:|..|:.....|.:..
Human   211 -DEEEEEEEDENEPPPV--------------IAPRPEHTKSIYTRSVVES--------------- 245

  Fly   240 IIKPAVGAQDA---GADDNPDETILRRS--KEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEV 299
            |..|||..::.   .|::....|:.|.:  :.|:::.||.||..:||:|.:..||:::|...:::
Human   246 IASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKI 310

  Fly   300 GKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQ 364
            |:||||.|:.|.|:....:||:|.::::.|..|:||:.||.|:::..:.|:||:||:||:  .|:
Human   311 GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--GDE 373

  Fly   365 LWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVK 429
            |||||||:.||.||||||||.|.|.|||.||||.|.|:.|||:..:|||||||||:|||||||||
Human   374 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVK 438

  Fly   430 VTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETP 493
            :|||||||.|..:: ||.|||||||||||||||||.||.||||||:|||||||:||:||||.|.|
Human   439 LTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 503

  Fly   494 LRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNI 558
            ||||||||.||.|::::.::||...:|||:|||:::||||.:|.|||.||||.....:.:|.|.|
Human   504 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 568

  Fly   559 KAAKKVLRRN 568
            .|||:.::.:
Human   569 IAAKEAIKNS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	23/90 (26%)
		PKc_like	288..545	CDD:304357	157/257 (61%)
		S_TKc	293..545	CDD:214567	155/252 (62%)
PAK3	NP_001121640.1	PBD	69..162	CDD:307091	24/92 (26%)
		STKc_PAK3	284..580	CDD:132987	171/297 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820