Protein Alignment Pak3 and PAK2

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_002568.2
• Gene: PAK2 / 5062
• HGNCID: 8591
• Length: 524
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 232/555 - (41%)
• Similarity: 313/555 - (56%)
• Gaps: 109/555 - (19%)

  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKK 82
            ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|....:|:|:.:..|:
Human    73 EISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQ 137

  Fly    83 ENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNS 147
            :...|.|                            |||   ||..:.|...::.|
Human   138 KYLSFTP----------------------------PEK---DGFPSGTPALNAKG---------- 161

  Fly   148 SSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRV 212
                     :..|....||...:.:|              .|||              |.|:|
Human   162 ---------TEAPAVVTEEEDDDEET--------------APPV--------------IAPRP-- 187

  Fly   213 TQKFSRTSDIRRDEDSDNQHKINTDTII--IKPAVGAQDAGADDNPDETILRRSKEKRAQK-TDA 274
                            |:...|.|.::|  :...||      |.:.|.......|:|:..| ||.
Human   188 ----------------DHTKSIYTRSVIDPVPAPVG------DSHVDGAAKSLDKQKKKTKMTDE 230

  Fly   275 EIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEI 339
            ||..:||.|.:..||:::|...:::|:||||.||.|.|:....:||:|.|:::.|..|:||:.||
Human   231 EIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEI 295

  Fly   340 RVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISF 404
            .|:|:..:.|:|||||:||:  .|:|:|||||:.||.||||||||.|.|.|||.||||.|.|:.|
Human   296 LVMKELKNPNIVNFLDSYLV--GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEF 358

  Fly   405 LHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKK 468
            |||..:||||||||||||||:||||:|||||||.|..:: ||.|||||||||||||||||.||.|
Human   359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 423

  Fly   469 VDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRR 533
            |||||:|||||||:||:||||.|.|||||||||.||.|::::.:||||..:|||:|||:::|::|
Human   424 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKR 488

  Fly   534 ATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
            .:|.|||.||||.....:.:|.|.|.|||:.::.|
Human   489 GSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSN 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	22/54 (41%)
		PKc_like	288..545	CDD:304357	161/257 (63%)
		S_TKc	293..545	CDD:214567	159/252 (63%)
PAK2	NP_002568.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		3/7 (43%)
		Autoregulatory region. /evidence=ECO:0000250	69..137		24/63 (38%)
		GTPase-binding. /evidence=ECO:0000250	69..112		14/38 (37%)
		PBD	73..130	CDD:307091	23/56 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..164		8/70 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..188		9/64 (14%)
		STKc_PAK2	229..524	CDD:132986	176/297 (59%)
		Nuclear localization signal	245..251		2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820