Protein Alignment Pak3 and PAK1

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001122092.1
• Gene: PAK1 / 5058
• HGNCID: 8590
• Length: 553
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 224/550 - (40%)
• Similarity: 313/550 - (56%)
• Gaps: 98/550 - (17%)

  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKK 82
            ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|....:::||  .||.
Human    74 EISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYN--SKKT 136

  Fly    83 ENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNS 147
            .|.                  :.|:::.:|       .::|..||.|...::.|  .:.|....|
Human   137 SNS------------------QKYMSFTDK-------SAEDYNSSNALNVKAVS--ETPAVPPVS 174

  Fly   148 SSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHT--IPPKPQIKPKP 210
            ...:|....:|                             ||||...:..||  :..:..|:|.|
Human   175 EDEDDDDDDAT-----------------------------PPPVIAPRPEHTKSVYTRSVIEPLP 210

  Fly   211 RVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQK---T 272
            ....:...||.|...|:       ||..                 ||  .|.|:.||:.:|   :
Human   211 VTPTRDVATSPISPTEN-------NTTP-----------------PD--ALTRNTEKQKKKPKMS 249

  Fly   273 DAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILT 337
            |.||..:||:|.:..||:::|...:::|:||||.|:.|.|:....:||:|.::::.|..|:||:.
Human   250 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIIN 314

  Fly   338 EIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAI 402
            ||.|:::..:.|:||:||:||:  .|:|||||||:.||.||||||||.|.|.|||.||||.|.|:
Human   315 EILVMRENKNPNIVNYLDSYLV--GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL 377

  Fly   403 SFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYG 466
            .|||:..:|||||||||:|||||||||:|||||||.|..:: ||.|||||||||||||||||.||
Human   378 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYG 442

  Fly   467 KKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVD 531
            .||||||:||||||||||:||||.|.|||||||||.||.|::::.:|||...:|||:|||:::|:
Human   443 PKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVE 507

  Fly   532 RRATADELLS-----HPFLNDCSEVKALVP 556
            :|.:|.|||.     ....::.|.:.|.:|
Human   508 KRGSAKELLQVRKLRFQVFSNFSMIAASIP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	22/54 (41%)
		PKc_like	288..545	CDD:304357	155/262 (59%)
		S_TKc	293..545	CDD:214567	153/257 (60%)
PAK1	NP_001122092.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		2/2 (100%)
		Autoregulatory region	70..140		27/85 (32%)
		PBD	74..128	CDD:334253	22/53 (42%)
		GTPase-binding	75..105		10/29 (34%)
		Interaction with CRIPAK. /evidence=ECO:0000269|PubMed:16278681	132..270		45/221 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..198		10/69 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..251		13/65 (20%)
		STKc_PAK_I	262..517	CDD:270814	154/256 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820