DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and MAP3K4

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_005913.3	Gene:	MAP3K4 / 4216	HGNCID:	6856	Length:	1608	Species:	Homo sapiens

Alignment Length:	461	Identity:	122/461 - (26%)
Similarity:	202/461 - (43%)	Gaps:	88/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPP 190
            ::.|....|.|| |.|....:.||.:|:...|....|.|..:..||:.....|.:.....::.|.
Human  1198 AAVAASRPSPSG-GDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA 1261

  Fly   191 VPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDN 255
            .|                              |.|.....:......|:|.:    ::|..:...
Human  1262 YP------------------------------RGDSSGSTRRSWELRTLISQ----SKDTASKLG 1292

  Fly   256 PDETI---LRRSKEKRAQKTDAEIYVELR------AICNSDDPRE--------------RYKTTQ 297
            |.|.|   :|..:|||        |.|:|      .:|  |.|:.              :::...
Human  1293 PIEAIQKSVRLFEEKR--------YREMRRKNIIGQVC--DTPKSYDNVMHVGLRKVTFKWQRGN 1347

  Fly   298 EVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILT--EIRVLKDFNHKNLVNFLDAYLLE 360
            ::|:|..|.|:....:.....:|:|.|..:....|.:..|  |:::.:...|.|||.:....|
Human  1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVEL-- 1410

  Fly   361 PEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMD 425
            ..:::::.|||.|.|.|.: |:...::|..|....::...||:.||..||:|||||..|:.|...
Human  1411 HREEMYIFMEYCDEGTLEE-VSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSS 1474

  Fly   426 GSVKVTDFGFCANIEGDEKRQTM-------VGTPYWMAPEVVTRKK---YGKKVDIWSIGIMAIE 480
            |.:|:.|||....::.:  .|||       :||..:|||||:||.|   :|:..||||:|.:.||
Human  1475 GLIKLGDFGCSVKLKNN--AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIE 1537

  Fly   481 MIEGQPP-YLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPF 544
            |:.|:.| :.||...:.:|.:....:|.|.  ::|||..:|||..||:.:...|.||.:||.|.|
Human  1538 MVTGKRPWHEYEHNFQIMYKVGMGHKPPIP--ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1600

  Fly   545 LNDCSE 550
            :..|::
Human  1601 VKVCTD 1606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	86/283 (30%)
		S_TKc	293..545	CDD:214567	85/264 (32%)
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1231		9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1274		5/59 (8%)
		STKc_MEKK4	1342..1601	CDD:270796	85/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910