DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak3 and MAP3K1

DIOPT Version :10

Sequence 1:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_005912.1 Gene:MAP3K1 / 4214 HGNCID:6848 Length:1512 Species:Homo sapiens


Alignment Length:524 Identity:139/524 - (26%)
Similarity:235/524 - (44%) Gaps:94/524 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 AVKYYNYSIKKKENEVFKPFITE------DVIH--EESKEIENYVNYKNKHKSQDPEKSDDDGSS 127
            :::::....:.|:::...|..|:      ..||  :.|:....     |..|..||.|     :|
Human  1026 SLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPG-----NTSKQGDPSK-----NS 1080

  Fly   128 TATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFK--ELKTNLEHRETLKAAPQEPPP 190
            ...:..|||.|..|.|.|::||      .:.:|.|  |.||.  |.|..|:....|.::.::...
Human  1081 MTLDLNSSSKCDDSFGCSSNSS------NAVIPSD--ETVFTPVEEKCRLDVNTELNSSIEDLLE 1137

  Fly   191 VPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQ---HKINT---DTIIIKPAVGA-Q 248
            .....|..|:..|.::..   ::.:.:...|..:|:.:.||   .|:..   :.:.|..|:.| |
Human  1138 ASMPSSDTTVTFKSEVAV---LSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQ 1199

  Fly   249 DA-----------GAD------DNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTT 296
            ||           |.|      |.| ||:...:|.|:..:.|.|                 :...
Human  1200 DALPIVPQLQVENGEDIIIIQQDTP-ETLPGHTKAKQPYREDTE-----------------WLKG 1246

  Fly   297 QEVGKGASGIVFIAADLQNESQVAVKTID-MKNQSSK-----DLILTEIRVLKDFNHKNLVNFLD 355
            |::|.||....:.|.|:...:.:|||.:. ::|.||:     :.:..|||::...||.|::..|.
Human  1247 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLG 1311

  Fly   356 AYLLEPEDQLWVVMEYMDGGPLTDVVTE-TVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDN 419
            |...:....|::  |:|.||.:..:::: ...||..:.....:.|..:|:||...|||||:|..|
Human  1312 ATCEKSNYNLFI--EWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGAN 1374

  Fly   420 VLLGMDGS-VKVTDFGFCANIE-----GDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMA 478
            :|:...|. :::.|||..|.:.     ..|.:..::||..:|||||:..::||:..|:||:|...
Human  1375 LLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAI 1439

  Fly   479 IEMIEGQPPYLYETPLRALYLI----AANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADEL 539
            |||...:||:..|.....|.||    :|...|.|.|  .|||.|:|...|||:::...|..:.||
Human  1440 IEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPS--HLSPGLRDVALRCLELQPQDRPPSREL 1502

  Fly   540 LSHP 543
            |.||
Human  1503 LKHP 1506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pak3NP_001262638.1 PBD 19..76 CDD:395634 0/4 (0%)
Protein Kinases, catalytic domain 288..545 CDD:473864 85/273 (31%)
MAP3K1NP_005912.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..181
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..304
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..436
RING-CH-C4HC3_ZSWM2 440..495 CDD:438157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..532
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 602..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 933..972
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1087 12/64 (19%)
STKc_MEKK1 1242..1509 CDD:270800 86/286 (30%)
Blue background indicates that the domain is not in the aligned region.

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