DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Taok2

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001157247.1	Gene:	Taok2 / 381921	MGIID:	1915919	Length:	1240	Species:	Mus musculus

Alignment Length:	313	Identity:	109/313 - (34%)
Similarity:	164/313 - (52%)	Gaps:	43/313 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIV 307
            ||.|.  ||:..:||.               ||::.:       |||.:.:...:|:|.|:.|.|
Mouse     2 PAGGR--AGSLKDPDV---------------AELFFK-------DDPEKLFSDLREIGHGSFGAV 42

  Fly   308 FIAADLQNESQVAVKTIDMKNQSSKDL---ILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVM 369
            :.|.|::|...||:|.:....:.|.:.   |:.|:|.|:...|.|.:.:...||  .|...|:||
Mouse    43 YFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYL--REHTAWLVM 105

  Fly   370 EYMDGGPLTDV--VTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTD 432
            ||..|. .:|:  |.:..::|.:||.|....|..:::||:..:||||:|:.|:||...|.||:.|
Mouse   106 EYCLGS-ASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGD 169

  Fly   433 FGFCANIEGDEKRQTMVGTPYWMAPEVV---TRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPL 494
            || .|:|..  ...:.|||||||||||:   ...:|..|||:||:||..||:.|.:||......:
Mouse   170 FG-SASIMA--PANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAM 231

  Fly   495 RALYLIAANGRPDIKS--WDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545
            .|||.||.|..|.::|  |   |...::|:|.|||.....|.|::.||.|.|:
Mouse   232 SALYHIAQNESPALQSGHW---SEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	98/266 (37%)
		S_TKc	293..545	CDD:214567	96/261 (37%)
Taok2	NP_001157247.1	STKc_TAO2	12..319	CDD:270804	104/301 (35%)
		S_TKc	28..281	CDD:214567	96/261 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..946
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1212..1240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910