Protein Alignment Pak3 and pak1

DIOPT Version :10

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_021323273.1
• Gene: pak1 / 373103
• ZFINID: ZDB-GENE-030826-29
• Length: 587
• Species: Danio rerio
• Alignment Length: 595
• Identity: 238/595 - (40%)
• Similarity: 329/595 - (55%)
• Gaps: 106/595 - (17%)

  Fly    11 GGDGGSIS----EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYH 70
            |||..:..    ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|...
Zfish    61 GGDKTNKKKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLD 125

  Fly    71 AVKYYNYSIKKKENEVFKPFITEDVIHEESKEIEN---YVNYKNKHKSQDPEKSDDDGSSTATET 132
            .:|:|                       :|||..|   |:::.:|
Zfish   126 VLKFY-----------------------DSKETSNNQKYMSFTDK-------------------- 147

  Fly   133 ESSSGCGSSAGNSNSSS------INDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPV 191
                    ...|.||||      ::::...:||..|..||         |...|       ||||
Zfish   148 --------GVENFNSSSAVVPKTVSETPAVATVSEDEDEE---------EDEAT-------PPPV 188

  Fly   192 PPKKSPHT--IPPKPQIKP-KPRVTQKFSRTSDIRR---------DEDSDNQHKINTDTIIIKPA 244
            ...:..||  |..:..|:| .|.::.|.:.||.|..         :..|.|.:..||:|......
Zfish   189 IAPRPEHTKSIYTRSVIEPLPPPLSTKDAATSPITNAAADGGSSSNAPSSNTNTTNTNTTNTTNT 253

  Fly   245 VG--AQDAGADDNPDETILRRSKEKRAQKTDAEIYVELR--------AICNSDDPRERYKTTQEV 299
            ..  :..|.:..|...|.....|.::.:.:|.||..:|.        :|.:..||:::|...:::
Zfish   254 TNTTSTSAASSTNAPSTPQTTDKSRKKKMSDEEILEKLNVLRSPSAGSIVSVGDPKKKYTRFEKI 318

  Fly   300 GKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQ 364
            |:||||.|:.|.|:....:||:|.::::.|..|:||:.||.|:::..:.|:||:||:||:  .|:
Zfish   319 GQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--GDE 381

  Fly   365 LWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVK 429
            |||||||:.||.||||||||.|.|.|||.||||.|.|:.|||...:|||||||||:|||||||||
Zfish   382 LWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNILLGMDGSVK 446

  Fly   430 VTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETP 493
            :|||||||.|..:: ||.|||||||||||||||||.||.||||||:||||||||||:||||.|.|
Zfish   447 LTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENP 511

  Fly   494 LRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNI 558
            ||||||||.||.|::::.:|||...:|||:|||:::|::|.:|.|||.|.||.....:.:|.|.|
Zfish   512 LRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELLQHQFLKVAKPLSSLTPLI 576

  Fly   559 KAAKKVLRRN 568
            .|||:..:.|
Zfish   577 IAAKEAAKNN 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..76	CDD:395634	23/57 (40%)
		Protein Kinases, catalytic domain	288..545	CDD:473864	156/257 (61%)
pak1	XP_021323273.1	PBD	73..130	CDD:395634	23/56 (41%)
		Protein Kinases, catalytic domain	283..586	CDD:473864	169/304 (56%)