DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and pak1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_021323273.1	Gene:	pak1 / 373103	ZFINID:	ZDB-GENE-030826-29	Length:	587	Species:	Danio rerio

Alignment Length:	595	Identity:	238/595 - (40%)
Similarity:	329/595 - (55%)	Gaps:	106/595 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGDGGSIS----EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYH 70
            |||..:..    ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|...
Zfish    61 GGDKTNKKKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLD 125

  Fly    71 AVKYYNYSIKKKENEVFKPFITEDVIHEESKEIEN---YVNYKNKHKSQDPEKSDDDGSSTATET 132
            .:|:|                       :|||..|   |:::.:|
Zfish   126 VLKFY-----------------------DSKETSNNQKYMSFTDK-------------------- 147

  Fly   133 ESSSGCGSSAGNSNSSS------INDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPV 191
                    ...|.||||      ::::...:||..|..||         |...|       ||||
Zfish   148 --------GVENFNSSSAVVPKTVSETPAVATVSEDEDEE---------EDEAT-------PPPV 188

  Fly   192 PPKKSPHT--IPPKPQIKP-KPRVTQKFSRTSDIRR---------DEDSDNQHKINTDTIIIKPA 244
            ...:..||  |..:..|:| .|.::.|.:.||.|..         :..|.|.:..||:|......
Zfish   189 IAPRPEHTKSIYTRSVIEPLPPPLSTKDAATSPITNAAADGGSSSNAPSSNTNTTNTNTTNTTNT 253

  Fly   245 VG--AQDAGADDNPDETILRRSKEKRAQKTDAEIYVELR--------AICNSDDPRERYKTTQEV 299
            ..  :..|.:..|...|.....|.::.:.:|.||..:|.        :|.:..||:::|...:::
Zfish   254 TNTTSTSAASSTNAPSTPQTTDKSRKKKMSDEEILEKLNVLRSPSAGSIVSVGDPKKKYTRFEKI 318

  Fly   300 GKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQ 364
            |:||||.|:.|.|:....:||:|.::::.|..|:||:.||.|:::..:.|:||:||:||:  .|:
Zfish   319 GQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV--GDE 381

  Fly   365 LWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVK 429
            |||||||:.||.||||||||.|.|.|||.||||.|.|:.|||...:|||||||||:|||||||||
Zfish   382 LWVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNILLGMDGSVK 446

  Fly   430 VTDFGFCANIEGDE-KRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETP 493
            :|||||||.|..:: ||.|||||||||||||||||.||.||||||:||||||||||:||||.|.|
Zfish   447 LTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENP 511

  Fly   494 LRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNI 558
            ||||||||.||.|::::.:|||...:|||:|||:::|::|.:|.|||.|.||.....:.:|.|.|
Zfish   512 LRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELLQHQFLKVAKPLSSLTPLI 576

  Fly   559 KAAKKVLRRN 568
            .|||:..:.|
Zfish   577 IAAKEAAKNN 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	22/54 (41%)
		PKc_like	288..545	CDD:304357	156/257 (61%)
		S_TKc	293..545	CDD:214567	154/252 (61%)
pak1	XP_021323273.1	PBD	73..130	CDD:307091	23/56 (41%)
pak1	XP_021323273.1	PKc_like	283..586	CDD:328722	169/304 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920