DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Myo3b

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001380706.1	Gene:	Myo3b / 366069	RGDID:	1560313	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	95/306 - (31%)
Similarity:	156/306 - (50%)	Gaps:	28/306 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SKEKRAQKTDAEIY---------VELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQV 319
            |.|....||...:|         :.|.::   .||.:.::..:.:|||..|.|:..|:.::.|..
  Rat     8 SGEHAEDKTGKHLYGLFHYNSMMLRLESL---PDPMDTWEIRETIGKGTYGKVYKVANRRDGSLA 69

  Fly   320 AVKTIDMKNQSSKDLILTEIRVLKDF-NHKNLVNFLDAYLLEPE---DQLWVVMEYMDGGPLTDV 380
            |||.:|..|...:: :..|..:|:.. :|.|:|.|...:.....   .|||:|:|..:||.:|::
  Rat    70 AVKILDSVNDVDEE-VEAEYNILQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTEL 133

  Fly   381 VTETV-----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIE 440
            |...:     :.|..|:.:...:|..:..||...|||||:|.:|:||..:|.||:.|||..|.:.
  Rat   134 VKGLLRCGKRLDEALISYILYGSLLGLQHLHHHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLT 198

  Fly   441 GDE-KRQTMVGTPYWMAPEVVTRKK-----YGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYL 499
            ... :|.|.||||:||||||:..::     |..:.|:||:||.|||:.:|.||.....|::.|:.
  Rat   199 STRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFK 263

  Fly   500 IAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545
            |..|..|.:...|........|:.:||..:.::|.:...||.|||:
  Rat   264 IPRNPPPTLLHPDNWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFI 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	88/271 (32%)
		S_TKc	293..545	CDD:214567	86/266 (32%)
Myo3b	NP_001380706.1	MYSc_Myo3	373..1062	CDD:276830
		IQ	1102..1124	CDD:197470
		PKc_like	20..310	CDD:419665	91/294 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910