DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and lok

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	113/431 - (26%)
Similarity:	197/431 - (45%)	Gaps:	98/431 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 KPRVTQKFSRTS-DIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKE----KR 268
            |.|:....|..| |:..||.:..:.:.| |.|:.          .:|.|::.:.|.||.    ||
  Fly    50 KYRIIYTHSSFSVDLNNDEFTAGRGEAN-DLILT----------LNDLPEKILTRISKVHFIIKR 103

  Fly   269 AQ-KTDAEIYVE------------------LRAICNSD-----------------DPRE------ 291
            |. :....:|::                  :|.:.|.|                 .|.|
  Fly   104 ANCELTNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPE 168

  Fly   292 ----RYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMK---------NQSSKDLILTEIRVLK 343
                .|...:::|.||.|:|.:..|.:...|.|:|.:...         |.|..|.:|.|.:::|
  Fly   169 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK 233

  Fly   344 DFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTD-VVTETVMKERQIACVCRETLYAISFLHA 407
            :.:|..:|...|  :::..|.:::|:|:|.||.|.: :::..::.|........:..:|:.:||.
  Fly   234 NLSHPCVVRMHD--IVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHD 296

  Fly   408 KGIIHRDIKSDNVLLGMDGS---VKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVT---RKKYG 466
            :||.|||:|.|||||..:..   :||:|||....::.|...:|:.|||.::||||:.   |:.|.
  Fly   297 RGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYT 361

  Fly   467 KKVDIWSIGIMAIEMIEGQPPYL--YETPLRALYLIA----ANGRPDIKSWDKLSPNLQDFLDRC 525
            |||||||:|::....:.|..|:.  |.||  |...|.    |.|.|   ||..:|...:..:::.
  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTP--AAQQIKKGRFAYGHP---SWKSVSQRAKLLINQM 421

  Fly   526 LQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLR 566
            |.|:.:||.:.|::|...:|.|       .|.::.||::::
  Fly   422 LIVDPERRPSIDDVLQSSWLRD-------APMLQKAKRLMK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	86/288 (30%)
		S_TKc	293..545	CDD:214567	84/273 (31%)
lok	NP_477219.1	FHA	39..156	CDD:238017	22/116 (19%)
		STKc_Chk2	167..441	CDD:270986	84/280 (30%)
		S_TKc	174..441	CDD:214567	84/273 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910