DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Myo3b

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_796350.2	Gene:	Myo3b / 329421	MGIID:	2448580	Length:	1333	Species:	Mus musculus

Alignment Length:	340	Identity:	105/340 - (30%)
Similarity:	167/340 - (49%)	Gaps:	34/340 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SKEKRAQKTDAEIY---------VELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQV 319
            |.|....||...:|         :.|.::   .||.|.::..:.:|||..|.|:..|:.::.|..
Mouse     8 SGEHTGDKTGKHLYGLFHYNPMMLGLESL---PDPMETWEIIETIGKGTYGKVYKVANKRDGSLA 69

  Fly   320 AVKTIDMKNQSSKDLILTEIRVLKDF-NHKNLVNFLDAYLLEPE---DQLWVVMEYMDGGPLTDV 380
            |||.:|..:...:: |..|..:|:.. :|.|:|.|...:.....   .|||:|:|..:||.:|::
Mouse    70 AVKVLDPVSDMDEE-IEAEYNILQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTEL 133

  Fly   381 VTETV-----MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIE 440
            |...:     :.|..|:.:....|..:..||...|||||:|.:|:||..:|.||:.|||..|.:.
Mouse   134 VKGLLRCGKRLDEAVISYILYGALLGLQHLHCHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLT 198

  Fly   441 GDE-KRQTMVGTPYWMAPEVVTRKK-----YGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYL 499
            ... :|.|.||||:||||||:..::     |..:.|:||:||.|||:.:|.||.....|::.|:.
Mouse   199 STRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFK 263

  Fly   500 IAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKV 564
            |..|..|.:...|........|:.:||..:.::|.:...||.|||:.. ::.|.|... |...||
Mouse   264 IPRNPPPTLLHPDSWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKG-TQGKVLCLQ-KQLAKV 326

  Fly   565 LR----RNVXLLCNH 575
            |:    ||......|
Mouse   327 LQDQKHRNPVAKTRH 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	89/271 (33%)
		S_TKc	293..545	CDD:214567	86/266 (32%)
Myo3b	NP_796350.2	STKc_myosinIIIB_N	20..310	CDD:270808	92/293 (31%)
		S_TKc	43..309	CDD:214567	86/266 (32%)
		MYSc	362..1069	CDD:214580
		MYSc_Myo3	373..1062	CDD:276830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910