DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Stk4

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001101270.1	Gene:	Stk4 / 311622	RGDID:	1312035	Length:	487	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	103/312 - (33%)
Similarity:	168/312 - (53%)	Gaps:	29/312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 ETI-LRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAV 321
            ||: ||....::.:|.|.:...:        .|.|.:...:::|:|:.|.|:.|...:....||:
  Rat     2 ETVQLRNPPRRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58

  Fly   322 KTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVV--TET 384
            |.:.:  :|....|:.||.:::..:..::|.:..:|....:  ||:||||...|.::|::  ...
  Rat    59 KQVPV--ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNK 119

  Fly   385 VMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANI-EGDEKRQTM 448
            .:.|.:||.:.:.||..:.:||....||||||:.|:||..:|..|:.|||....: :...||.|:
  Rat   120 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV 184

  Fly   449 VGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDK 513
            :|||:||||||:....|....||||:||.||||.||:|||....|:||:::|..|..|..:..:.
  Rat   185 IGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEV 249

  Fly   514 LSPNLQDFLDRCLQVEVDRRATADELLSHPF-------------LNDCSEVK 552
            .|.|..||:.:||....::||||.:||.|||             :|:..:||
  Rat   250 WSDNFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGAAILRDLINEAMDVK 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	94/272 (35%)
		S_TKc	293..545	CDD:214567	92/267 (34%)
Stk4	NP_001101270.1	STKc_MST1_2	26..281	CDD:132943	93/258 (36%)
Stk4	NP_001101270.1	Mst1_SARAH	433..480	CDD:402983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910