DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and Pak5

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001101251.1	Gene:	Pak5 / 311450	RGDID:	1312009	Length:	718	Species:	Rattus norvegicus

Alignment Length:	709	Identity:	208/709 - (29%)
Similarity:	304/709 - (42%)	Gaps:	179/709 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMNSQITRDEQDKNPD-------AAYHAVKYYN 76
            ||..|:||:...|...:.:.....|||..|..|:.....|.:...:|.       |....:...|
  Rat    10 EISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGN 74

  Fly    77 YSIKK----------------KENEVFKP---------------------FITEDVIHEESKEIE 104
            .|.|:                :.|.:.|.                     |||......||....
  Rat    75 KSCKESSINGLLEDFDNISVTRSNSLRKESPPTPDQGAASRIQGHSEENGFITFSQYSSESDTTT 139

  Fly   105 NYVN----------------YKNKHKSQD------------------PEKSD------D-----D 124
            :|..                |:..|.::.                  |.|||      |     |
  Rat   140 DYTTEKYRDRSLYGDDLDLYYRGSHAAKQNGHAMKMKHGDAYYPEMKPLKSDLARFPVDYHTHLD 204

  Fly   125 GSSTATE----------TESSSGCGSS--------AGNSNSS-------------SIND------ 152
            ..|.|:|          ..|||....|        ||.|..|             |.:|
  Rat   205 SLSKASEYGDLKWDYQRASSSSPLDYSFQLTPSRTAGTSRCSKESLAYSESDWGPSFDDYDRRPK 269

  Fly   153 -SSQQSTVPLDALEEVFKELKTNLEH------RETLKAAPQ-------------EP----PPV-- 191
             |....|.|..|:.:..|. .:.|:.      ....|..||             ||    |.|
  Rat   270 SSYLHQTSPQPAMRQRSKS-GSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDY 333

  Fly   192 --------PPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHK--------INTDTII 240
                    ||.....|.|..|...|:.:....:|.:|     ......||        :.|.:..
  Rat   334 DRAQMVFSPPLSGSDTYPRGPTKLPQSQSKVGYSSSS-----HQYPGYHKASLYHHPSLQTSSQY 393

  Fly   241 IKPA--VGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGA 303
            |..|  :.:....:...|..:....|.::.::.:..:....|:.:.:..||||......::|:|:
  Rat   394 ISTASYLSSLSISSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLDNFIKIGEGS 458

  Fly   304 SGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVV 368
            :|||.||.:.....|||||.:|::.|..::|:..|:.:::|::|.|:|:..::||:  .|:||||
  Rat   459 TGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLV--GDELWVV 521

  Fly   369 MEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDF 433
            ||:::||.|||:||.|.|.|.|||.||...|.|:|:||.:|:||||||||::||..||.:|::||
  Rat   522 MEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDF 586

  Fly   434 GFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRAL 497
            ||||.:..: .||:::|||||||||||::|..||.:|||||:|||.||||:|:|||..|.||:|:
  Rat   587 GFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAM 651

  Fly   498 YLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVP 556
            ..|..:..|.:|...|:|..|:.|||..|..|..:||||.|||.||||........:||
  Rat   652 RRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	14/60 (23%)
		PKc_like	288..545	CDD:304357	129/257 (50%)
		S_TKc	293..545	CDD:214567	125/252 (50%)
Pak5	NP_001101251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		6/18 (33%)
		CRIB_PAK_like	9..55	CDD:238526	12/44 (27%)
		Linker. /evidence=ECO:0000250	25..447		72/427 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..119		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..245		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..296		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..371		8/36 (22%)
		STKc_PAK5	425..716	CDD:132989	134/288 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820