DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak3 and Map3k3

DIOPT Version :10

Sequence 1:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_001100528.1 Gene:Map3k3 / 303604 RGDID:1304575 Length:626 Species:Rattus norvegicus


Alignment Length:570 Identity:144/570 - (25%)
Similarity:244/570 - (42%) Gaps:125/570 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 TNFQRHFHVSR------NQETGDLEGL-PAPWVRLMNSQITRDEQDKN-------PDAAYHAVKY 74
            |:...|..|||      :|..||:..: .||..|..:..::.....::       |:...|..:.
  Rat   128 TSSSPHSGVSRQVRVKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQ 192

  Fly    75 YNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDD---DGSSTATETESSS 136
            .:|:....|.|    ||                          ||.|:.   |..|:| |...|.
  Rat   193 GSYTSINSEGE----FI--------------------------PETSEQCMLDPLSSA-ENSLSG 226

  Fly   137 GCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIP 201
            .|.|...:::|.|.. .||.|..      ..|.:.:.....|||                     
  Rat   227 SCQSLDRSADSPSFR-KSQMSRA------RSFPDNRKECSDRET--------------------- 263

  Fly   202 PKPQIKPK-------PR---VTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNP 256
               |:..|       ||   |:......:|.||......:|:.|..|::  |:..:..... :|.
  Rat   264 ---QLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLV--PSSRSLSTNG-ENM 322

  Fly   257 DETILRRSKEKRAQKTDAE--IYVELRAI-CNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQ 318
            ...:.......|.:..|:|  :.|:.|:: ..|......::..:.:|:||.|.|::..|:....:
  Rat   323 GAAVQYLDPRGRLRSADSENALTVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE 387

  Fly   319 VAVKTIDM---KNQSSKDL--ILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLT 378
            :|.|.:..   ..::||::  :..||::||:..|:.:|.:........|..|.:.||||.||.:.
  Rat   388 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVK 452

  Fly   379 D------VVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFG--- 434
            |      .:||:|.::     ..|:.|..:|:||:..|:|||||..|:|....|:||:.|||   
  Rat   453 DQLKAYGALTESVTRK-----YTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASK 512

  Fly   435 ----FCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLR 495
                .|.:..|   .:::.||||||:|||::.:.||:|.|:||:|...:||:..:||:.....:.
  Rat   513 RLQTICMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574

  Fly   496 ALYLIAAN-GRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPF 544
            |::.||.. ..|.:.|  .:|.:.:|||.| :.||..:|.:|:|||:|.|
  Rat   575 AIFKIATQPTNPQLPS--HISEHGRDFLRR-IFVEARQRPSAEELLTHHF 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pak3NP_001262638.1 PBD 19..76 CDD:395634 13/65 (20%)
Protein Kinases, catalytic domain 288..545 CDD:473864 88/276 (32%)
Map3k3NP_001100528.1 PB1_Mekk2_3 45..123 CDD:99726
STKc_MEKK3_like 361..621 CDD:270795 87/270 (32%)
Blue background indicates that the domain is not in the aligned region.

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