DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Pak6

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001099968.1	Gene:	Pak6 / 296078	RGDID:	1306213	Length:	681	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	208/730 - (28%)
Similarity:	323/730 - (44%)	Gaps:	224/730 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTKWFKKKGGDGGSISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMN-----------SQI 56
            |.|..||:       .||.||.|||...|.|.:.:.|...|||..|..:::           |:|
  Rat     2 FRKKKKKR-------PEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRI 59

  Fly    57 TRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYV-------------- 107
            ||.:                          .:|..|  |:...|...|.|:
  Rat    60 TRVQ--------------------------LQPMKT--VVRGSSVPTEGYISGLLNDIQKLSAIS 96

  Fly   108 -------NYKNKHKSQ------------DP---------EKSDDDG--------------SSTAT 130
                   :..::.::|            ||         |::|..|              .:...
  Rat    97 SNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSERTDPHGVYLSCNGGTPAGHRQTPWP 161

  Fly   131 ETES----SSGCGSSAGNSNSSSINDSSQ---------QSTVP----------------LDALEE 166
            |.:|    .:|..:.|.:...:....:||         ||:.|                ..:.||
  Rat   162 EPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGTSPPMATGRRGVKVTKHSSEE 226

  Fly   167 VF---------------------KELKTNLEHR----------ETLKAAPQEPPPVPPKK----- 195
            ..                     |..:::|:||          .|..|:..:|.|:|..|
  Rat   227 ARPQSCLVGSAIGRPGGEGSPSPKTQESSLKHRLFRSMFLSTPATGSASSSKPVPLPQNKLNSAF 291

  Fly   196 ------SPHTIPPKPQIKPKPRVTQKFS--RTSDIRRDEDS--------------------DNQH 232
                  |...:..|.|..|..:.|..||  .|||....:.|                    ..:|
  Rat   292 RPPQKDSSSNLVAKAQSLPSDQPTGTFSPLTTSDTSSPQKSLRTAPATGPLPGRSSPAGSPRTRH 356

  Fly   233 -KINT-------DTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDP 289
             :|:|       |..:.|.|:|.:|.|        |:...:.|.|          ||.:.:..||
  Rat   357 AQISTSNLYLPQDPTVAKGALGGEDTG--------IVTHEQFKAA----------LRMVVDQGDP 403

  Fly   290 RERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFL 354
            |....:..::|:|::|||.:|.:..:..|||||.:|::.|..::|:..|:.:::|:.|.|:|...
  Rat   404 RLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMY 468

  Fly   355 DAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDN 419
            .:||:  .::|||:||::.||.|||::::..:.|.|||.||...|.|:::|||:|:||||||||:
  Rat   469 KSYLV--GEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 531

  Fly   420 VLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIE 483
            :||.:||.||::||||||.|..| .||:::|||||||||||::|..|..:|||||:|||.|||::
  Rat   532 ILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVD 596

  Fly   484 GQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDC 548
            |:|||..::|::|:..:..:..|.:|:..|:||.|:|||:|.|..|...||||.|||.||||...
  Rat   597 GEPPYFSDSPVQAMKRLRDSPPPKLKNSYKVSPVLRDFLERMLVREPQERATAQELLDHPFLLQT 661

  Fly   549 SEVKALVPNIKAAKK 563
            ...:.|||.|:..:|
  Rat   662 GLPECLVPLIQLYRK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	18/64 (28%)
		PKc_like	288..545	CDD:304357	121/257 (47%)
		S_TKc	293..545	CDD:214567	118/252 (47%)
Pak6	NP_001099968.1	PBD	11..67	CDD:395634	18/81 (22%)
Pak6	NP_001099968.1	STKc_PAK6	385..681	CDD:270821	132/304 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820