DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak3 and Pak2

DIOPT Version :9

Sequence 1:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_001380632.1 Gene:Pak2 / 29432 RGDID:61953 Length:524 Species:Rattus norvegicus


Alignment Length:572 Identity:241/572 - (42%)
Similarity:321/572 - (56%) Gaps:112/572 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SFTKWFKKKGGDGGSISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNP 65
            |..|..|||..:.   .||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||
  Rat    59 STEKGSKKKEKER---PEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP 120

  Fly    66 DAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTAT 130
            .|....:|:|:.:..|::...|.|                            |||   ||..:.|
  Rat   121 QAVLDVLKFYDSNTVKQKYLSFTP----------------------------PEK---DGFPSGT 154

  Fly   131 ETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKK 195
            ...::.|..:||                        |..|     |..:...|||          
  Rat   155 PALNTKGSETSA------------------------VVTE-----EDDDDEDAAP---------- 180

  Fly   196 SPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTII--IKPAVGAQDAGADDNPDE 258
                    |.|.|:|                  |:...|.|.::|  |...||      |.|.|.
  Rat   181 --------PVIAPRP------------------DHTKSIYTRSVIDPIPAPVG------DSNVDS 213

  Fly   259 TILRRSKE-KRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVK 322
            ......|: |:|:.||.||..:||.|.:..||:::|...:::|:||||.||.|.|:....:||:|
  Rat   214 GAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIK 278

  Fly   323 TIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMK 387
            .|:::.|..|:||:.||.|:|:..:.|:|||||:||:  .|:|:|||||:.||.||||||||.|.
  Rat   279 QINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLV--GDELFVVMEYLAGGSLTDVVTETCMD 341

  Fly   388 ERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGT 451
            |.|||.||||.|.|:.||||..:||||||||||||||:||||:|||||||.|..:: ||.|||||
  Rat   342 EAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGT 406

  Fly   452 PYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSP 516
            ||||||||||||.||.||||||:|||||||:||:||||.|.|||||||||.||.|::::.:||||
  Rat   407 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSP 471

  Fly   517 NLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
            ..:|||:|||:::|::|.:|.|||.||||.....:.:|.|.|.|||:.::.|
  Rat   472 IFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSN 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pak3NP_001262638.1 PBD 19..73 CDD:279166 22/54 (41%)
PKc_like 288..545 CDD:304357 161/257 (63%)
S_TKc 293..545 CDD:214567 159/252 (63%)
Pak2NP_001380632.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..81 8/24 (33%)
Autoregulatory region. /evidence=ECO:0000250 69..137 24/70 (34%)
GTPase-binding. /evidence=ECO:0000250 69..112 14/45 (31%)
PBD 73..130 CDD:395634 23/56 (41%)
Linker 88..248 62/261 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..190 22/143 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..228 8/29 (28%)
STKc_PAK2 229..524 CDD:132986 176/297 (59%)
Nuclear localization signal. /evidence=ECO:0000250 245..251 2/5 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0578
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D425477at33208
OrthoFinder 1 1.000 - - FOG0000763
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100484
Panther 1 1.100 - - O PTHR48015
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.820

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