DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and STK39

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_037365.2	Gene:	STK39 / 27347	HGNCID:	17717	Length:	545	Species:	Homo sapiens

Alignment Length:	316	Identity:	108/316 - (34%)
Similarity:	170/316 - (53%)	Gaps:	39/316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 ICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDM-KNQSSKDLILTEIRVLKDFN 346
            ||     |:.|:..:.:|.||:.:|..|.....:.:||:|.|:: |.|:|.|.:|.||:.:...:
Human    58 IC-----RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS 117

  Fly   347 HKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVV---------TETVMKERQIACVCRETLYAI 402
            |.|:|.:..::::  :|:||:||:.:.||.:.|::         ...|::|..||.:.:|.|..:
Human   118 HPNVVTYYTSFVV--KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180

  Fly   403 SFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA------NIEGDEKRQTMVGTPYWMAPEVVT 461
            .:||..|.||||:|:.|:|||.||||::.|||..|      ::..::.|:|.||||.||||||:.
Human   181 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVME 245

  Fly   462 R-KKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRP-------DIKSWDKLSPNL 518
            : :.|..|.|:||.||.|||:..|..||....|::.|.|...|..|       |.:...|...:.
Human   246 QVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSF 310

  Fly   519 QDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALV-------PNI-KAAKKVLR 566
            :..|..|||.:..:|.||.|||...|.......:.|:       |:| :.||||.|
Human   311 RKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	97/280 (35%)
		S_TKc	293..545	CDD:214567	96/275 (35%)
STK39	NP_037365.2	STKc_OSR1_SPAK	61..337	CDD:270787	96/277 (35%)
		S_TKc	63..337	CDD:214567	96/275 (35%)
		Interaction with RELT. /evidence=ECO:0000250\|UniProtKB:Q9Z1W9	310..536		19/57 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	360..366		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..423		5/6 (83%)
		Caspase cleavage related site	387..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910