DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and shk1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_596626.1	Gene:	shk1 / 2539997	PomBaseID:	SPBC1604.14c	Length:	658	Species:	Schizosaccharomyces pombe

Alignment Length:	545	Identity:	211/545 - (38%)
Similarity:	294/545 - (53%)	Gaps:	43/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMN-SQITRDEQDKNPDAAYHAVKYYNYSIKKKE 83
            |.:|.:.:...||..|.:||:..|:|..|..|:. |.||:.||.::|.|...|:.:|:.|.|..|
pombe   147 ISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLE 211

  Fly    84 NEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSS 148
            .....||                           |.:|.:....:.:...|||....::..|:||
pombe   212 EGAKPPF---------------------------PRESTEKPLLSVSALSSSSHLQPTSATSSSS 249

  Fly   149 SINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVT 213
            .:..|....|.|..:.....  |.:......|..|:.|..|.|..|.:.:.|.....:...|: |
pombe   250 RLYPSRPAPTPPASSSSSPL--LSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQ-T 311

  Fly   214 QKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGA--QDAGADDNPDETILRRSKEKRAQKTDAEI 276
            ...|.|..||.:..:..|.:..|.|   ||...|  |...|...|    ..:.:..|.|..|:.:
pombe   312 LSTSETKHIRPNNSTPYQRRAETST---KPKAVATPQKVEAPSAP----RLQKRAPRQQSNDSAV 369

  Fly   277 YVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRV 341
            ..:|::|||..:|...|:...::|:||||.|:.|..:.....||:|.:::..|..|:.|:.||.|
pombe   370 LAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILV 434

  Fly   342 LKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLH 406
            :|..:|||:|||:|.:..:.|  ||:|||||.||.||:|||...:.|.|||.:|:|||..:..||
pombe   435 MKSHHHKNIVNFIDTFFYKSE--LWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLH 497

  Fly   407 AKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVD 470
            ..||:||||||||:||.:.|.:|:|||||||.|:.: .||.|||||||||||||||||:||.|||
pombe   498 ENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVD 562

  Fly   471 IWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRAT 535
            :||:|||||||:||:||||.|.|||||||||..|.|.|...:.||....|||.:.|.|...:|.:
pombe   563 VWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPS 627

  Fly   536 ADELLSHPFLNDCSEVKALVPNIKA 560
            :.|||.||||.....|.:|:|.||:
pombe   628 SGELLRHPFLKQAVPVSSLIPLIKS 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	19/53 (36%)
		PKc_like	288..545	CDD:304357	138/257 (54%)
		S_TKc	293..545	CDD:214567	137/252 (54%)
shk1	NP_596626.1	PBD	146..200	CDD:279166	18/52 (35%)
		STKc_PAK	385..638	CDD:270789	138/254 (54%)
		S_TKc	391..637	CDD:214567	136/247 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.770