DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and mug27

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_588283.1	Gene:	mug27 / 2539482	PomBaseID:	SPCC417.06c	Length:	624	Species:	Schizosaccharomyces pombe

Alignment Length:	519	Identity:	124/519 - (23%)
Similarity:	206/519 - (39%)	Gaps:	136/519 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 KEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALE 165
            ||::|     ||..|    |:.::|...:.....|||......|: |:|::..:::.
pombe     7 KELDN-----NKLVS----KAKENGVEFSDLFLLSSGYLRDRENA-SASVSSKNERM-------- 53

  Fly   166 EVFKELKTN----------LEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTS 220
             |..|.:.|          |.:.:.||.:..|            |..:|:.:.|....|.|....
pombe    54 -VLNEERQNCWTKRNDPKGLTYYQLLKPSEVE------------ILSRPETRRKRMACQVFFLNY 105

  Fly   221 DIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICN 285
            .|...|    .||:..:.:            .:.....:.|::||:||..|..          |.
pombe   106 YISTIE----YHKLRKERL------------EEFTACTSSLKQSKQKRLWKEH----------CG 144

  Fly   286 SDDPRERYKTTQ----------EVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDL-----I 335
            .:....|.|.|:          ::|:|..|.|::|........:|:|.  ||..:.:.|     |
pombe   145 RERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKM--MKKSTLQQLNEVKHI 207

  Fly   336 LTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPL-TDVVTETVMKERQIACVCRETL 399
            |.|..:|.:.|.:.||...  |..:.::::::.|||:.||.. |.:.|:.::.|.|......|.:
pombe   208 LNERDILTNTNSEWLVKLY--YAFQDKEKVYLAMEYVPGGDFRTFLTTKGLLHENQTRFYLAEMV 270

  Fly   400 YAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANI------------------------- 439
            .|||.:|..|.:|||:|.:|.|:...|.:|::|||....|
pombe   271 AAISAVHKLGYMHRDLKPENFLIDQKGHIKLSDFGLSTAIVTSNQVNRLQHALVSAVNPQRPYLT 335

  Fly   440 -------------EGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPY--- 488
                         :.:.|..::||:|.:||||||..|||.:.||.||:|.:..|.:.|.||:
pombe   336 QKQRRNIYKALLEKNENKVNSVVGSPEYMAPEVVYGKKYDRTVDYWSLGCICYECLVGYPPFSGS 400

  Fly   489 -LYETPLRALYLIAANGRPDIKS---WDKLSPNLQD----FLDRCLQVEVDRRATADELLSHPF 544
             |.||.....|......||....   :||.:.::.|    |:.:||.....|..:..|:..|||
pombe   401 TLQETWTNLYYWREMLQRPSKNENGIYDKKARSVSDEAWSFITKCLTEPTSRFQSTIEIQKHPF 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	87/322 (27%)
		S_TKc	293..545	CDD:214567	86/317 (27%)
mug27	NP_588283.1	STKc_Sid2p_like	150..540	CDD:270751	87/319 (27%)
mug27	NP_588283.1	S_TKc	162..465	CDD:214567	84/307 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910