DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Camk1d

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_796317.2	Gene:	Camk1d / 227541	MGIID:	2442190	Length:	385	Species:	Mus musculus

Alignment Length:	297	Identity:	92/297 - (30%)
Similarity:	159/297 - (53%)	Gaps:	26/297 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 SDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKD-LILTEIRVLKDFNHKN 349
            ::|.::.::..:.:|.||...|.:|.:.......|||.|..|....|: .|..||.||:...|:|
Mouse    16 AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHEN 80

  Fly   350 LVNFLDAYLLEPEDQLWVVMEYMDGGPLTD-VVTETVMKERQIACVCRETLYAISFLHAKGIIHR 413
            :|...|.|  |..:.|::||:.:.||.|.| :|.:....|:..:.:.|:.|.|:.:||..||:||
Mouse    81 IVALEDIY--ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHR 143

  Fly   414 DIKSDNVLL---GMDGSVKVTDFGFCANIEG-DEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSI 474
            |:|.:|:|.   ..:..:.::|||. :.:|| .:...|..|||.::||||:.:|.|.|.||.|||
Mouse   144 DLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSI 207

  Fly   475 GIMAIEMIEGQPPY-------LYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDR 532
            |::|..::.|.||:       |:|..|:|.|..      |...||.:|.:.:||:...::.:.::
Mouse   208 GVIAYILLCGYPPFYDENDSKLFEQILKAEYEF------DSPYWDDISDSAKDFIRNLMEKDPNK 266

  Fly   533 RATADELLSHPFLNDCSEVKALVPNI-KAAKKVLRRN 568
            |.|.::...||::   :...||..|| ::....:|:|
Mouse   267 RYTCEQAARHPWI---AGDTALSKNIHESVSAQIRKN 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	86/269 (32%)
		S_TKc	293..545	CDD:214567	85/264 (32%)
Camk1d	NP_796317.2	STKc_CaMKI_delta	12..312	CDD:271070	92/297 (31%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		6/25 (24%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000250	318..324
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910