DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Map3k19

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_035867.2	Gene:	Map3k19 / 22625	MGIID:	1203481	Length:	1515	Species:	Mus musculus

Alignment Length:	540	Identity:	138/540 - (25%)
Similarity:	222/540 - (41%)	Gaps:	114/540 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ITEDVIHEESKEIENYVNYKNKHKS----QDPEKSDDDG------SSTATETESSSGCGSSAGNS 145
            |.|::..||..:.|..:|..:..:|    ::||......      :|.|..:|..||...|....
Mouse  1001 IVEEIFTEECADEEGILNDDSLTQSLGDLKEPEGLHPQAPLVPSENSWAVLSEKRSGKRVSPEKH 1065

  Fly   146 NSSSINDSSQQSTVP----LDALEEVFKELK--TNLEHRETLKAAPQEPPPVPPKKSPHTIPPKP 204
            |...::..:.:...|    .|:|.|..|.|.  ::...:|.|:.||.     |.::.......:.
Mouse  1066 NVEPLDKINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQENLERAPS-----PTEQHWARSLEQD 1125

  Fly   205 QIKPKPRVTQKFSRTSD-----------------------IRRDEDSDNQHKINTDTIIIKPAVG 246
            .::......|.|.:.|.                       :..||..:|..:|.|:....|
Mouse  1126 SLENNSTTYQTFGKISQEILDPGKNEELTDELLGCLVEELLALDEKDNNSCQIMTNEADAK---- 1186

  Fly   247 AQDAGADDNPDETILRRS---KEKRAQKTDAEIYVELRAICNS----DDPRERYKTTQE------ 298
                    |.:....||.   :|...:.||    |:|:...|.    |:  |.:.|:.|
Mouse  1187 --------NLNLVFSRRGNTIEELGRETTD----VKLQRCINGFRIYDE--ENFLTSNEKKTLSD 1237

  Fly   299 ----------------VGKGASGIVFIA----ADLQNESQVAVKTIDMKNQSSKDL--ILTEIRV 341
                            :|:||.|.|:..    ..|....|||:.|.| |..:.|:.  :..|:.:
Mouse  1238 KSLNHEEAIFWTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDTSD-KLATEKEYRKLQEEVDL 1301

  Fly   342 LKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIAC-VCRETLYAISFL 405
            ||...|.|:|.:|...|  .|:.|.:.||::.||.::.::.........:.| ..|:.|..:::|
Mouse  1302 LKALKHVNIVAYLGTCL--EENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYL 1364

  Fly   406 HAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA--------NIEGDEKRQTMVGTPYWMAPEVVTR 462
            |...::|||||.:||:|...|.:|:.||| ||        |....:..::|.||||||||||:..
Mouse  1365 HDNCVVHRDIKGNNVMLMPTGIIKLIDFG-CAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINE 1428

  Fly   463 KKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANG--RPDIKSWDKLSPNLQDFLDRC 525
            ..||:|.||||||....||..|:||......:.|::.|.|:.  .|.:.:  :.|....||:..|
Mouse  1429 SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPA--RFSEPAADFVRLC 1491

  Fly   526 LQVEVDRRATADELLSHPFL 545
            |..:...|.:|.:||.|.||
Mouse  1492 LTRDQHERPSALQLLKHSFL 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	90/295 (31%)
		S_TKc	293..545	CDD:214567	89/290 (31%)
Map3k19	NP_035867.2	ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1246..1511	CDD:270801	87/270 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000