DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Pak6

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001028426.2	Gene:	Pak6 / 214230	MGIID:	2679420	Length:	682	Species:	Mus musculus

Alignment Length:	732	Identity:	209/732 - (28%)
Similarity:	321/732 - (43%)	Gaps:	227/732 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTKWFKKKGGDGGSISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMN-----------SQI 56
            |.|..||:       .||.||.|||...|.|.:.:.|...|||..|..:::           |:|
Mouse     2 FRKKKKKR-------PEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRI 59

  Fly    57 TRDEQDKNPDAAYHAVKYYNYSIKKKENEVFKPFITEDVIHEESKEIENYVN------------- 108
            ||.:                          .:|..|  |:...|...|.|::
Mouse    60 TRVQ--------------------------LQPMKT--VVRGSSVPTEGYISGLLNDIQKLSVIS 96

  Fly   109 ----------YKNKHKS-----------------QDPEKSDDD---------GSSTA-------T 130
                      .:.:.:|                 |.|:....|         |.:.|       .
Mouse    97 SNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSEHTDPHGLYLSCNGGTPAGHRQVPWP 161

  Fly   131 ETES----SSGCGSSAGNSNSSSINDSSQQSTVPLDAL--------------------------E 165
            |.:|    .:|..:.|.:...:....:||:....|.|.                          |
Mouse   162 EPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGRRGVKVAKHSSE 226

  Fly   166 EVF---------------------KELKTNLEHR----------ETLKAAPQEPPPVPPKKSPHT 199
            |..                     |..:::|:||          .|..|:..:|.|:|..| |::
Mouse   227 EARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAASSSKPVPLPQNK-PNS 290

  Fly   200 I--PP----------KPQIKPKPRVTQKFS--RTSDIRRDEDS--------------------DN 230
            .  ||          |.|..|..:....||  .|||....:.|                    ..
Mouse   291 AFRPPQKDSSSNLVAKAQSLPSEQPMGTFSPLTTSDTSSPQKSLRTAPAAGPLPGRSSPAGSPRT 355

  Fly   231 QH-KINT-------DTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSD 287
            :| :|:|       |..:.|.|:|.:|.|        |:...:.|.|          ||.:.:..
Mouse   356 RHAQISTSNLYLPQDPTVAKGALGGEDTG--------IVTHEQFKAA----------LRMVVDQG 402

  Fly   288 DPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVN 352
            |||....:..::|:|::|||.:|.:..:..|||||.:|::.|..::|:..|:.:::|:.|.|:|.
Mouse   403 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVE 467

  Fly   353 FLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKS 417
            ...:||:  .::|||:||::.||.|||::::..:.|.|||.||...|.|:::|||:|:|||||||
Mouse   468 MYKSYLV--GEELWVLMEFLQGGALTDIISQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKS 530

  Fly   418 DNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEM 481
            |::||.:||.||::||||||.|..| .||:::|||||||||||::|..|..:|||||:|||.|||
Mouse   531 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEM 595

  Fly   482 IEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLN 546
            ::|:|||..::|::|:..:..:..|.:|:..|:||.|:|||||.|..|...||||.|||.||||.
Mouse   596 VDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREPQERATAQELLDHPFLL 660

  Fly   547 DCSEVKALVPNIKAAKK 563
            .....:.|||.|:..:|
Mouse   661 QTGLPECLVPLIQLYRK 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	18/64 (28%)
		PKc_like	288..545	CDD:304357	122/257 (47%)
		S_TKc	293..545	CDD:214567	119/252 (47%)
Pak6	NP_001028426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		13/34 (38%)
		PBD	11..63	CDD:334253	18/51 (35%)
		Linker. /evidence=ECO:0000250	26..407		70/427 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..170		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..256		3/55 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..367		21/97 (22%)
		STKc_PAK6	386..682	CDD:270821	133/304 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820