DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and mkk-4

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_509682.1	Gene:	mkk-4 / 185682	WormBaseID:	WBGene00003368	Length:	363	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	95/368 - (25%)
Similarity:	156/368 - (42%)	Gaps:	53/368 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 DEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAE-IYVELRAICNSDD 288
            ||:..|...:...::..:|...:.:......|:|::||.......:..|.| :|....|  |..|
Worm     6 DENLRNSMSLRPTSLSTRPTSLSVNGNEKTLPEESVLRSLSTGTLKYPDDEHLYTFSSA--NLQD 68

  Fly   289 PRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFN------- 346
                   ...:|.|..|.|:.....:....:|||.|...|...::    :||:|::.:
Worm    69 -------LGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHRE----QIRLLREHDTIVKSEK 122

  Fly   347 HKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-------MKERQIACVCRETLYAISF 404
            ..|:|.|..|  :..|...|:.||.||..  .|::.:.|       :.|..:..:...|:.|:.:
Worm   123 GPNIVKFYGA--IFSEGDCWICMELMDIS--MDLLYKRVYMVKNSRLNENVVGHITVCTVDALDY 183

  Fly   405 LHAK-GIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRK-KYGK 467
            |..: .|||||:|..|:|:...|:||:.|||.|..:|....:....|...::|||.:|.. ||..
Worm   184 LKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITSSDKYDV 248

  Fly   468 KVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQD---------FLD 523
            :.|:||:||...|:..|:.||.....|........:|.|.|     |.|:..|         |::
Worm   249 RSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPI-----LHPDSDDFHYSLPLVKFIN 308

  Fly   524 RCLQVEVDRRATADELLSHPFLNDCSEVKALV-PNIKAAKKVL 565
            .||..:...|...|.|.|..|.    .:.|:. |.|:.||::|
Worm   309 TCLTKDRRHRPKYDTLKSFDFY----RIYAVAGPEIEEAKRIL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	75/281 (27%)
		S_TKc	293..545	CDD:214567	74/276 (27%)
mkk-4	NP_509682.1	PKc_MKK4	59..347	CDD:270790	84/313 (27%)
mkk-4	NP_509682.1	S_TKc	72..329	CDD:214567	74/269 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910