Protein Alignment Pak3 and Pak1

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001344291.1
• Gene: Pak1 / 18479
• MGIID: 1339975
• Length: 552
• Species: Mus musculus
• Alignment Length: 563
• Identity: 230/563 - (40%)
• Similarity: 322/563 - (57%)
• Gaps: 98/563 - (17%)

  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYYNYSIKKK 82
            ||..|::|:...||..:..||:..|:|..|.||: .|.||:.||.|||.|....:::||  .||.
Mouse    74 EISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYN--SKKT 136

  Fly    83 ENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNS 147
            .|.                  :.|:::.:|                            ||.:.||
Mouse   137 SNS------------------QKYMSFTDK----------------------------SAEDYNS 155

  Fly   148 SSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRV 212
            |                         |..:.:|:...|..||....:.......|.|.|.|:|..
Mouse   156 S-------------------------NTLNVKTVSETPAVPPVSEDEDDDDDATPPPVIAPRPEH 195

  Fly   213 TQKFSRTSDIRRDEDSDNQHKINTDTIIIK-PAVGAQD-AGADDNPDET------ILRRSKEKRA 269
            |:.|.:          .:|.::.|.::|.. |....:| |.:..:|.|.      .|.|:.||:.
Mouse   196 TKSFGQ----------KDQREVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQK 250

  Fly   270 QK---TDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSS 331
            :|   :|.||..:||:|.:..||:::|...:::|:||||.|:.|.|:....:||:|.::::.|..
Mouse   251 KKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK 315

  Fly   332 KDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCR 396
            |:||:.||.|:::..:.|:||:||:||:  .|:|||||||:.||.||||||||.|.|.|||.|||
Mouse   316 KELIINEILVMRENKNPNIVNYLDSYLV--GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR 378

  Fly   397 ETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDE-KRQTMVGTPYWMAPEVV 460
            |.|.|:.|||:..:|||||||||:|||||||||:|||||||.|..:: ||.||||||||||||||
Mouse   379 ECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 443

  Fly   461 TRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRC 525
            |||.||.||||||:||||||||||:||||.|.|||||||||.||.|::::.:|||...:|||:||
Mouse   444 TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 508

  Fly   526 LQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
            |:::|::|.:|.|||.|.||.....:.:|.|.|.|||:..:.|
Mouse   509 LEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNN 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	22/54 (41%)
		PKc_like	288..545	CDD:304357	156/257 (61%)
		S_TKc	293..545	CDD:214567	154/252 (61%)
Pak1	NP_001344291.1	PBD	74..128	CDD:334253	22/53 (42%)
		STKc_PAK1	256..551	CDD:270820	170/296 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820