DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and Phkg2

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_542151.1	Gene:	Phkg2 / 140671	RGDID:	620024	Length:	406	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	90/312 - (28%)
Similarity:	162/312 - (51%)	Gaps:	32/312 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 ERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKD----------- 344
            ::|.....:|:|.|.:|..........:.|||.:::   |::.|.|.::..::|
  Rat    22 QKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEV---SAERLSLEQLEEVRDATRREMHILRQ 83

  Fly   345 -FNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETV-MKERQIACVCRETLYAISFLHA 407
             ..|.:::..:|:|  |....:::|.:.|..|.|.|.:||.| :.|::...:.|..|.|::|||.
  Rat    84 VAGHPHIITLIDSY--ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNFLHV 146

  Fly   408 KGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVV------TRKKYG 466
            ..|:|||:|.:|:||..:..::::||||..::|..||.:.:.|||.::|||::      |...||
  Rat   147 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYG 211

  Fly   467 KKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKS--WDKLSPNLQDFLDRCLQVE 529
            |:||:|:.|::...::.|.||:.:...:..|.:| ..|:....|  ||..|..::|.:.:.|||:
  Rat   212 KEVDLWACGVILFTLLAGSPPFWHRRQILMLRMI-MEGQYQFSSPEWDDRSNTVKDLIAKLLQVD 275

  Fly   530 VDRRATADELLSHPFLNDC--SEVKALVPNIK---AAKKVLRRNVXLLCNHR 576
            .:.|.||::.|.|||...|  |:...|.|..:   |...:|.... .|.:||
  Rat   276 PNARLTAEQALQHPFFERCKGSQPWNLTPRQRFRVAVWTILAAGRVALSSHR 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	80/274 (29%)
		S_TKc	293..545	CDD:214567	80/272 (29%)
Phkg2	NP_542151.1	STKc_PhKG2	13..291	CDD:271083	80/274 (29%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		5/22 (23%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910