DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and AgaP_AGAP009730

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_318814.4	Gene:	AgaP_AGAP009730 / 1279139	VectorBaseID:	AGAP009730	Length:	1581	Species:	Anopheles gambiae

Alignment Length:	310	Identity:	106/310 - (34%)
Similarity:	162/310 - (52%)	Gaps:	26/310 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 DPRERYKTTQEVGKGASGIVFIAADLQ-NESQVAVKTIDMKNQSSKDLILTEIRVLKDFN-HKNL 350
            ||..|||..:.:|.|....|:.|.|.| ....||:|....:.: :|..|..|.|:|:|.: |.||
Mosquito    11 DPGNRYKLGELIGSGVCAKVYRATDTQAGNKNVAIKVQKFEGE-TKTAIQEEFRILRDHSKHANL 74

  Fly   351 VNFLDAYLLE-PE---DQLWVVMEYMDGGPLTDVVTETVMKER-----QIACVCRETLYAISFLH 406
            ::|...|..: |.   |::|.|:||.|.||..|||.:..:..|     |:|.:.||...|:.:||
Mosquito    75 IDFYGIYRKKCPAGECDEIWFVLEYCDYGPAVDVVRKLFVNNRRASELQLAYILREVSRALVYLH 139

  Fly   407 AKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKK-----Y 465
            ...|:|||::..|:||..||.||:.|:|...:.:.. .||.|.:|:|.||||||||..|     |
Mosquito   140 EHHIVHRDVRGSNILLTKDGEVKLCDYGLARDTKSTLGKRGTCIGSPCWMAPEVVTSSKSDKDVY 204

  Fly   466 GKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEV 530
            ..:.|:|::||.|||:.:|:||:......||::.|..|..|.:......|....||:..||:...
Mosquito   205 DNRSDVWALGITAIELGDGKPPFADMHATRAMFQIVRNPPPTLYRQSNWSQEYNDFIAECLEKNP 269

  Fly   531 DRRATADELLSHPFL-----ND---CSEVKALVPNIKAAKKVLRRNVXLL 572
            |.|....|::.||||     ||   ..|:|.|..::::.:...:..|.::
Mosquito   270 DHRPFIMEVIEHPFLTQVPENDYHLSQELKMLAESVQSTQLPKKEEVAVV 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	98/273 (36%)
		S_TKc	293..545	CDD:214567	95/268 (35%)
AgaP_AGAP009730	XP_318814.4	PKc_like	9..284	CDD:304357	98/273 (36%)
		S_TKc	16..284	CDD:214567	95/268 (35%)
		MYSc	330..1051	CDD:214580
		MYSc_Myo21	347..1039	CDD:276848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910