DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and AgaP_AGAP003180

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_312877.4	Gene:	AgaP_AGAP003180 / 1273851	VectorBaseID:	AGAP003180	Length:	431	Species:	Anopheles gambiae

Alignment Length:	301	Identity:	80/301 - (26%)
Similarity:	143/301 - (47%)	Gaps:	55/301 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 ERYKTTQEVGKGASGIVFIAADLQNESQVAVKT-IDMKNQSS-KDLILTEIRVLKDFNHKNLVNF 353
            :||:....:|:|:.|:|:...|.:..|.||||. ::.::..: :.:.|.|||:||:..|.|||..
Mosquito    82 DRYEKLSRLGEGSYGVVYKCRDRETGSLVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVCL 146

  Fly   354 LDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQ---IAC-------VCRETLYAISFLHAK 408
            |:.:  ..:.:|.:|.|:.:         .||:.|.:   ..|       :..:|:..:::.|.:
Mosquito   147 LEVF--RRKRRLHLVFEFCE---------HTVLHELERHPEGCPDNLTKQITYQTIQGVAYCHKQ 200

  Fly   409 GIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPE-VVTRKKYGKKVDIW 472
            |.:|||||.:|:||...|.||:.||||...:...|.....|.|.::.||| :|...:||..||:|
Mosquito   201 GCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVW 265

  Fly   473 SIGIMAIEMIEGQPPYLYETPLRALYLIAAN------------------------GRPDIKSWDK 513
            :||.:..|::.|...:...:.:..||||...                        ..|.:::.:.
Mosquito   266 AIGCVFAELVRGDALWPGRSDVDQLYLIRRTLGDLLPRHLAIFNQNEFFKGITLPVPPTLETLEA 330

  Fly   514 LSPN-------LQDFLDRCLQVEVDRRATADELLSHPFLND 547
            ..|:       :.|||.:||..:..:|.:.:.|.:||:..|
Mosquito   331 KMPSRTLANPLMMDFLKKCLDKDPAKRWSCERLATHPYFED 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	79/297 (27%)
		S_TKc	293..545	CDD:214567	78/295 (26%)
AgaP_AGAP003180	XP_312877.4	STKc_CDKL1_4	82..369	CDD:270837	79/297 (27%)
AgaP_AGAP003180	XP_312877.4	Pkinase	84..369	CDD:278497	78/295 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910