DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and AgaP_AGAP011295

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_309350.4	Gene:	AgaP_AGAP011295 / 1270635	VectorBaseID:	AGAP011295	Length:	738	Species:	Anopheles gambiae

Alignment Length:	226	Identity:	64/226 - (28%)
Similarity:	101/226 - (44%)	Gaps:	34/226 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 YMDGGPLTD-VVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDG-------- 426
            |.:||.|.| :..:..:.|..|.....:...|:..|:...::|||:|..|:||..:.
Mosquito     1 YCNGGDLADYLAVKGTLSEDTIRLFLGQLANAMKALYQADVVHRDLKPQNILLSHNCGKGLPIPS 65

  Fly   427 --SVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYL 489
              ::|:.||||...::......|:.|:|.:|||||:...:|..|.|:||:|.:..:.:.|:.|:.
Mosquito    66 KITLKIADFGFARFLQDGNMAATLCGSPMYMAPEVIMSLQYDAKADLWSLGTIVFQCLTGKAPFQ 130

  Fly   490 YETP--LRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLN------ 546
            ..||  |:..|...||..|.|.|  ..|..|.|.|...|:.....|...|...:||||.
Mosquito   131 AHTPQELKMFYERNANLAPKIPS--GTSKELTDLLMGLLRRNAKERMNFDTFFNHPFLQRAETPQ 193

  Fly   547 -----DCSEVKALVPNIKAAKKVLRRNVXLL 572
                 :.:||...:|        ||.:|.:|
Mosquito   194 GKNGFNIAEVTVAIP--------LRESVSIL 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	55/186 (30%)
		S_TKc	293..545	CDD:214567	55/186 (30%)
AgaP_AGAP011295	XP_309350.4	S_TKc	<1..186	CDD:214567	55/186 (30%)
		PKc_like	<1..185	CDD:304357	54/185 (29%)
		DUF3543	532..726	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910