DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and AgaP_AGAP007333

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_308496.4	Gene:	AgaP_AGAP007333 / 1269844	VectorBaseID:	AGAP007333	Length:	561	Species:	Anopheles gambiae

Alignment Length:	346	Identity:	99/346 - (28%)
Similarity:	166/346 - (47%)	Gaps:	53/346 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 DETILRRSKEKRAQKTDAEIYVELRAICN-----------SDD----------PRERYKTTQEVG 300
            :|..||.|.:......|.::..||....|           |:|          |:: ::..:.:|
Mosquito    11 EEEDLRDSDDDIIDIEDVDLEPELHINTNLETEGSETIPLSEDIINPGRIKLGPQD-FELKKVLG 74

  Fly   301 KGASGIVF-----IAADLQNESQVAVKTID----MKNQSSKDLILTEIRVLKDFNHKNLVNFLDA 356
            ||..|.||     ..||.  .|..|:|.:.    ::||........|..:|:...|..:|..:
Mosquito    75 KGGYGKVFQVRKTTGADA--NSYFAMKVLKKASIVRNQKDTAHTRAERNILEAVRHPFIVELV-- 135

  Fly   357 YLLEPEDQLWVVMEYMDGGPL-TDVVTETVMKERQIAC--VCRETLYAISFLHAKGIIHRDIKSD 418
            |..:...:|::::||:.||.| ..:..|.:..| ..||  :| |.:.|:..||..|||:||:|.:
Mosquito   136 YAFQTGGKLYLILEYLSGGELFMHLEREGIFLE-DTACFYLC-EIILALEHLHNLGIIYRDLKPE 198

  Fly   419 NVLLGMDGSVKVTDFGFC-ANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMI 482
            ||||...|.||:||||.| .:|:......|..||..:||||::||..:||.||.||:|.:..:|:
Mosquito   199 NVLLDAKGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDML 263

  Fly   483 EGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRR-----ATADELLSH 542
            .|.||:..:...:.:..|..: :.:|..:  |:|:.:|.:.|.::.:|.:|     .....:.:|
Mosquito   264 TGMPPFCADNRKKTVDAILKD-KLNIPGY--LTPDSRDLIRRLMKRQVSQRLGSGPTDGQAVRAH 325

  Fly   543 PFLNDCS--EV--KALVPNIK 559
            ||..:.:  :|  :.|.|.||
Mosquito   326 PFFKNVNWDDVVKRRLDPPIK 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	84/284 (30%)
		S_TKc	293..545	CDD:214567	82/269 (30%)
AgaP_AGAP007333	XP_308496.4	S_TKc	67..328	CDD:214567	82/269 (30%)
AgaP_AGAP007333	XP_308496.4	STKc_p70S6K	71..392	CDD:270736	88/285 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910