DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and BUB1B-PAK6

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001122100.1	Gene:	BUB1B-PAK6 / 106821730	HGNCID:	52276	Length:	681	Species:	Homo sapiens

Alignment Length:	694	Identity:	207/694 - (29%)
Similarity:	328/694 - (47%)	Gaps:	152/694 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTKWFKKKGGDGGSISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMN-----------SQI 56
            |.|..||:       .||.||.|||...|.|.:.:.|...|||..|..:::           |:|
Human     2 FRKKKKKR-------PEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRI 59

  Fly    57 TRDEQDKNPDAAYHAVKYYNYSIKKKENEVFK-PFITEDVIHEES----KEIENYVNYKNKHKSQ 116
            ||.:..........:....:..|....|::.| ..|:.:.:...|    :..::.....::|.:.
Human    60 TRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWAT 124

  Fly   117 DP---------EKSDD-------DGSSTA-------TETES----SSGCGSSAGNSNSSSINDSS 154
            ||         |::|.       :|.:.|       .|.:|    .:|..:.|.:...:....:|
Human   125 DPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGAS 189

  Fly   155 Q---------QSTVP------------LDALEEVFKELK-------------------------T 173
            |         ||:.|            :.|.:...:|.:                         :
Human   190 QRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRES 254

  Fly   174 NLEHR-------ETLKAAPQE-----PPPV--------PPKK-SPHTIPPKPQIKPKPRVTQKFS 217
            :|:.|       .|...||..     |||.        ||:| :|.::..|.|..|..:....||
Human   255 SLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFS 319

  Fly   218 --RTSDIRRDEDSDNQHKINTDTIIIKPAVG-----AQDAGADDN-------------PDETILR 262
              .|||     .|..|..:.|     .||.|     :..||:...             .|.|:.:
Human   320 PLTTSD-----TSSPQKSLRT-----APATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAK 374

  Fly   263 --RSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTID 325
              .:.|.....|..:....||.:.:..|||....:..::|:|::|||.:|.:..:..|||||.:|
Human   375 GALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMD 439

  Fly   326 MKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQ 390
            ::.|..::|:..|:.:::|:.|.|:|....:||:  .::|||:||::.||.|||:|::..:.|.|
Human   440 LRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLV--GEELWVLMEFLQGGALTDIVSQVRLNEEQ 502

  Fly   391 IACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYW 454
            ||.||...|.|:::|||:|:||||||||::||.:||.||::||||||.|..| .||:::||||||
Human   503 IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYW 567

  Fly   455 MAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQ 519
            |||||::|..|..:|||||:|||.|||::|:|||..::|::|:..:..:..|.:|:..|:||.|:
Human   568 MAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 632

  Fly   520 DFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKK 563
            |||:|.|..:...||||.|||.||||......:.|||.|:..:|
Human   633 DFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	18/64 (28%)
		PKc_like	288..545	CDD:304357	121/257 (47%)
		S_TKc	293..545	CDD:214567	118/252 (47%)
BUB1B-PAK6	NP_001122100.1	PBD	11..67	CDD:307091	18/55 (33%)
BUB1B-PAK6	NP_001122100.1	STKc_PAK6	385..681	CDD:270821	131/294 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820