DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak3 and wnk2

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_009304513.1	Gene:	wnk2 / 103911868	ZFINID:	ZDB-GENE-160114-3	Length:	2247	Species:	Danio rerio

Alignment Length:	451	Identity:	118/451 - (26%)
Similarity:	198/451 - (43%)	Gaps:	77/451 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 TLKAAPQEP-----PPVPPKKS----------PHTIP--------PKPQIKP----KPRVTQKFS 217
            |..:|.|:|     |.||.||:          .||.|        ..|...|    :..|.|:|.
Zfish     5 TGSSAEQQPVGSTGPSVPSKKTVIYENGHAHPTHTDPAAAAHRGASDPTAYPLSDYRGLVRQRFI 69

  Fly   218 RTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDA-----------GADDNPDETILRRSKEKRAQK 271
            |.| :...|..|.:.::....|...|...|..|           |..|..:|.:   |||....:
Zfish    70 RRS-LWFSESEDQELEVAECDITSSPVKSAHIAIQRSFNKESQVGQADGTNENL---SKEPETSE 130

  Fly   272 TDA------------------EIYVELRAICNSDDPRERY-KTTQEVGKGASGIVFIAADLQNES 317
            |:.                  |...|::|:  |..|..|: |...|:|:|:...|:...|.:...
Zfish   131 TEEKQDAEQAEAAGKAGSDENEEEAEMKAV--STSPGGRFLKFDIELGRGSFKTVYKGLDTETWV 193

  Fly   318 QVA-VKTIDMK-NQSSKDLILTEIRVLKDFNHKNLVNFLDAY--LLEPEDQLWVVMEYMDGGPL- 377
            :|| .:..|.| :::.:.....|..:||...|.|:|.|.|.:  .|:.:..:.:|.|.|..|.|
Zfish   194 EVAWCELQDRKLSKAERQRFKEEAEMLKGLQHPNIVRFYDFWESPLKGKKCIVLVTELMTSGTLK 258

  Fly   378 TDVVTETVMKERQIACVCRETLYAISFLHAK--GIIHRDIKSDNVLL-GMDGSVKVTDFGFCANI 439
            |.:....|||.:.:...||:.|..:.|||.:  .|||||:|.||:.: |..||||:.|.|. |.:
Zfish   259 TYLKRFKVMKPKVLRSWCRQILKGLHFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGL-ATL 322

  Fly   440 EGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANG 504
            :.....::::|||.:||||:. .:.|.:.||:::.|:..:||...:.||........:|....:|
Zfish   323 KRASFAKSVIGTPEFMAPEMY-EEHYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG 386

  Fly   505 -RPDIKSWDKLS-PNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKK 563
             :|  .|:.|:: |.:::.:..|:....:.|.:..:||:|.|..:.:.|:..:......||
Zfish   387 VKP--ASFCKVAVPEIKEIIGECICHRWEERYSIKDLLNHAFFAEDTGVRVELAEEDDGKK 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	78/267 (29%)
		S_TKc	293..545	CDD:214567	76/262 (29%)
wnk2	XP_009304513.1	STKc_WNK	167..427	CDD:270885	77/263 (29%)
		OSR1_C	448..485	CDD:314980
		Atrophin-1	<736..1079	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910