DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pak3 and PAK4

DIOPT Version :9

Sequence 1:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_001014831.1 Gene:PAK4 / 10298 HGNCID:16059 Length:591 Species:Homo sapiens


Alignment Length:617 Identity:189/617 - (30%)
Similarity:294/617 - (47%) Gaps:105/617 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMNSQITRDEQDKNP------------------ 65
            ||.||:||:...|...:|......|||..|..|:.....|.:...:|                  
Human    10 EISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGS 74

  Fly    66 ----DAAYHAV--KYYNYSI----------------KKKENEV-FKPFIT------------EDV 95
                |.|...:  ::.|.|:                .::||.: .:|..|            ...
Human    75 KGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFA 139

  Fly    96 IHEESKEIENYVNYKNKHKSQDPE---KSDDDGSSTATETESSS--------GCGSSAGNSNSSS 149
            .|.|:.      ......:...||   ||..:||....|:....        |....||.::.:.
Human   140 GHSEAG------GGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAK 198

  Fly   150 INDSSQQSTVPLDALEEVFKELKTNLEH-RETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVT 213
            :......:|.|           :.:.:| ....:..|.:..|..|......||.......:|...
Human   199 LAAGRPFNTYP-----------RADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTR 252

  Fly   214 QKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIY- 277
            .:.:.:..:.....|:.|         :.|......|.|...|...   ||.::..|:...|.: 
Human   253 ARGAPSPGVLGPHASEPQ---------LAPPACTPAAPAVPGPPGP---RSPQREPQRVSHEQFR 305

  Fly   278 VELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVL 342
            ..|:.:.:..|||.......::|:|::|||.||....:...||||.:|::.|..::|:..|:.::
Human   306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIM 370

  Fly   343 KDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHA 407
            :|:.|:|:|...::||:  .|:||||||:::||.|||:||.|.|.|.|||.||...|.|:|.|||
Human   371 RDYQHENVVEMYNSYLV--GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHA 433

  Fly   408 KGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDI 471
            :|:||||||||::||..||.||::||||||.:..: .:|:::||||||||||:::|..||.:|||
Human   434 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDI 498

  Fly   472 WSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATA 536
            ||:|||.|||::|:|||..|.||:|:.:|..|..|.:|:..|:||:|:.||||.|..:..:||||
Human   499 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATA 563

  Fly   537 DELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
            .|||.||||.......::||       ::|:|
Human   564 AELLKHPFLAKAGPPASIVP-------LMRQN 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pak3NP_001262638.1 PBD 19..73 CDD:279166 17/77 (22%)
PKc_like 288..545 CDD:304357 128/257 (50%)
S_TKc 293..545 CDD:214567 125/252 (50%)
PAK4NP_001014831.1 CRIB_PAK_like 10..55 CDD:238526 14/44 (32%)
Linker 25..320 51/323 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..301 34/234 (15%)
GEF-interaction domain (GID) 298..323 5/24 (21%)
STKc_PAK4 300..591 CDD:132988 136/298 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0578
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D757766at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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