DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and dclk3

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_017950468.2	Gene:	dclk3 / 100493379	XenbaseID:	XB-GENE-983282	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	496	Identity:	126/496 - (25%)
Similarity:	230/496 - (46%)	Gaps:	68/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KENEVFKPFITEDVIHEESKEIENYVNYKNKHKSQDPEKSDDDG-------------SSTATETE 133
            |...::.....:|:..|.|..|..:..:.||.:|::.:|...:.             :....:|:
Frog   299 KYRNIYNRDYEKDISFEGSGTISLHGLHFNKEESKNCKKCPLENIQEEELRLKCKACNCKWKDTK 363

  Fly   134 SSSGCGSSAGNSNSSSINDSS-QQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSP 197
            ..:..|....|:|......:. |:|.:|.:.|..  ||||.| :.|:.|..       ...:|..
Frog   364 RETIIGDDLINNNIEMYEKTDWQESRLPKENLYR--KELKKN-QCRDVLDG-------FSVRKHL 418

  Fly   198 HTIPPKPQIKPKPRVTQKFSRT--SDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETI 260
            :.:......:||    |..||.  .:|..:.|..|:.:...|..|:|     .:||....|.:.
Frog   419 NGLLQNDSEEPK----QSMSRLHGDNITINNDYGNKKEKTKDPQILK-----TEAGPGGFPPKL- 473

  Fly   261 LRRSKEKRAQKTDAE---IYVELRAIC--NSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVA 320
                      ::||:   ::...|..|  .|.|....|:..:.:|.|...:|.:........:.|
Frog   474 ----------RSDAKGNCLFTLKRPCCIKTSRDIESYYEIGRTIGDGNFAVVKVCRPWNENQEYA 528

  Fly   321 VKTID-MKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTET 384
            :|.|| .|.:..:|:|..|:|::|..:|.|:|.....|  |.|.::::::||:.||.|.||:||:
Frog   529 MKIIDKSKLRGKEDIIENEVRIIKHLSHPNIVKLFSDY--ETEKEIYLILEYIRGGDLFDVITES 591

  Fly   385 V-MKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLL--GMDG--SVKVTDFGFCANIEGDEK 444
            : ..|...|.:..:...|:.::|:|.|:|||:|.:|:|:  ..||  |:|:.|||......|  .
Frog   592 IKFTEHDAALMLIDLCEALKYIHSKHIVHRDLKPENLLVQHNPDGSKSLKLADFGLAIYATG--P 654

  Fly   445 RQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLR---ALYLIAANGRP 506
            ..|:.|||.::|||:::.|.||.|||:|:.|::...::.|.||  :.:|.|   .|:.|..:|..
Frog   655 IFTVCGTPTYVAPEILSEKGYGLKVDMWATGVILYILLCGFPP--FRSPDRNQEELFQIIQSGEY 717

  Fly   507 DI--KSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545
            :.  ..||.:|..::|.:.:.|.:..:.|.:|..:|.|.::
Frog   718 EFLPPYWDHISEEVKDLISKLLVLNPEIRYSAKCVLQHSWV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	82/267 (31%)
		S_TKc	293..545	CDD:214567	81/262 (31%)
dclk3	XP_017950468.2	DCX_DCLK3	87..171	CDD:340528
dclk3	XP_017950468.2	STKc_DCKL3	500..757	CDD:271087	81/262 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910