DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and nuak1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_002931675.2	Gene:	nuak1 / 100491029	XenbaseID:	XB-GENE-980289	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	163/344 - (47%)	Gaps:	61/344 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 GAQDAGAD-----------------DNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERY 293
            |..:.|||                 |..|:|....:|:...::..           :..:.:.||
Frog     5 GKPEPGADAKSPVVGLAEQMHLSPCDEEDDTAGALAKQHGVKRHH-----------HKHNLKHRY 58

  Fly   294 KTTQEVGKGASGIVFIAADLQNESQVAVKTIDM-KNQSSKDL--ILTEIRVLKDFNHKNLVNFLD 355
            :..:.:|||..|.|..|.:..:...||:|:|.. |.:..:|:  |..||.::...||.:::...:
Frog    59 ELLETLGKGTYGKVKRAIERFSGRVVAIKSIRKDKIRDEQDMVHIRREIEIMSSLNHPHIIRIYE 123

  Fly   356 AYLLEPEDQLWVVMEYMDGGPLTDVVTE-TVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDN 419
            .:  |.:|::.::|||...|.|.|.::| ..:.||:.....|:.:.|:.:.|..|::|||:|.:|
Frog   124 VF--ENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLEN 186

  Fly   420 VLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKY-GKKVDIWSIGIMAIEMIE 483
            :||..:|::|:.|||.....:.|:..||..|:|.:.:||:|..:.| |.:||.|::|::...::.
Frog   187 ILLDENGNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY 251

  Fly   484 GQPP---YLYETPLRALYLIAANGRPDIKSWDKLSP----NLQDFLDRCLQVEVDRRATADELLS 541
            |..|   :.::..:|           .|.|.:...|    :.:..:...|.|..:||||.:::.:
Frog   252 GTMPFDGFDHKNLIR-----------QISSGEYREPTQPSDARGLIRWMLMVNPERRATIEDIAN 305

  Fly   542 HPFLN--------DCSEVK 552
            |.::|        ||..::
Frog   306 HWWVNWSYKSSVCDCDVLR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	73/268 (27%)
		S_TKc	293..545	CDD:214567	72/263 (27%)
nuak1	XP_002931675.2	STKc_NUAK	56..309	CDD:270975	73/265 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910