DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and map3k1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_012822348.1	Gene:	map3k1 / 100490504	XenbaseID:	XB-GENE-1008434	Length:	1445	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	132/521 - (25%)
Similarity:	219/521 - (42%)	Gaps:	100/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KYYNYSIKKKENEVFKPFITE------DVIHEESKEIENYVNYKNKHKSQDPEKSDD--DGSSTA 129
            |:|:.|   ||.|...|..|:      ..||...         .::....||.|..:  .||.|.
Frog   969 KHYSGS---KEPEKLSPVFTQARPLPSPQIHRPK---------PSRPTPGDPGKPGEAQKGSLTL 1021

  Fly   130 TETESS-SGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPP 193
            ....|. ..||     ||.|::..|......|::....:....:.|....:.|:|:      :|.
Frog  1022 DLNVSPYDNCG-----SNVSAVIPSDDTVFTPVEEKCRLDANTELNSSMEDLLEAS------MPA 1075

  Fly   194 KKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQ---HKINTD----TIIIKPAVGAQDA- 250
            ..|..|...:..:....|     :.|.:..:|:.:.||   .|:..:    ..|:.....:|||
Frog  1076 CDSTVTFKSEVAVLSSER-----AETDNTYKDDVNHNQKCKEKMEAEEEEALAIVLAMSASQDAL 1135

  Fly   251 ----------GAD------DNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEV 299
                      |.|      |.| ||:...:|.:...:.:.|                 :...|::
Frog  1136 PVIPQLQVQNGEDIIIIQQDTP-ETLPGHTKARNHYREEME-----------------WLKGQQI 1182

  Fly   300 GKGASGIVFIAADLQNESQVAVKTID-MKNQSSK-----DLILTEIRVLKDFNHKNLVNFLDAYL 358
            |.||....:.|.|:...:.:|||.:. ::|.|::     :.:..|||::...:|.|::..|.|..
Frog  1183 GLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSTEQGEVVEALREEIRMMSHLSHPNIIRMLGATC 1247

  Fly   359 LEPEDQLWVVMEYMDGGPLTDVVTE-TVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLL 422
            .:....|::  |:|.||.:..:::: ...||..|.....:.|..:|:||...|||||||..|:|:
Frog  1248 EKSNYNLFI--EWMAGGSVALLLSKYGAFKELVIINYAEQLLRGLSYLHENQIIHRDIKGANLLI 1310

  Fly   423 GMDGS-VKVTDFGFCANIE-----GDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEM 481
            ...|. :::.|||..|.:.     ..|.:..::||..:|||||:..::||:..|:||:|...|||
Frog  1311 DSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSLGCSIIEM 1375

  Fly   482 IEGQPPYLYETPLRALYLI----AANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSH 542
            ...:||:..|.....|.||    :|...|.|.  ..|||.|:|...|||:::...|..:.|||.|
Frog  1376 ACAKPPWNAEKHSNHLALIFKIASATTAPTIP--PHLSPGLRDVTLRCLELQPQDRPPSRELLKH 1438

  Fly   543 P 543
            |
Frog  1439 P 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	132/521 (25%)
		PKc_like	288..545	CDD:304357	84/273 (31%)
		S_TKc	293..545	CDD:214567	84/268 (31%)
map3k1	XP_012822348.1	RING-CH-C4HC3_ZSWM2	377..432	CDD:319408
		RING-CH finger (C4HC3-type)	380..428	CDD:319408
		STKc_MEKK1	1175..1442	CDD:270800	85/286 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910