DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and map3k19

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_002941471.3	Gene:	map3k19 / 100488738	XenbaseID:	XB-GENE-6046272	Length:	1285	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	106/484 - (21%)
Similarity:	170/484 - (35%)	Gaps:	155/484 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RDEQDKNPDAAYHAV------------KYYNYSIKKKEN--EVFKPFITEDVIHEE---SKE--I 103
            |||.....:...|.|            |..|.....||:  .|.:|| .:::.||:   .||  |
Frog   869 RDEDCAIEEKVEHGVIVISGTDWQIIEKSNNILFDSKESVAVVLEPF-QDNIYHEDLSMIKEATI 932

  Fly   104 ENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQ-STVPLDALEEV 167
            ||.:|                 :|.....:...|.|....|...:.:....|. .:||
Frog   933 ENSLN-----------------TSRTFHDDRVKGSGEMNPNHFDAEVFIQEQPIKSVP------- 973

  Fly   168 FKELKTNLEHRETLKAAPQEPPPVPPKKSPHT--IPPKPQIKPKPRVTQK--------FSRTSDI 222
                .|:...|||..::.|: ..:...|..:|  :|........||.|.:        ||::...
Frog   974 ----STDSHKRETRSSSAQQ-EELEDYKVDNTGGVPSCENKNNAPRETTEGGTENGYGFSKSLST 1033

  Fly   223 RRD----------------------EDSDNQHKINTDTIIIKPAVGAQDAGADDNPDETILRRSK 265
            ..|                      |..|:...|||||                  |:.|:....
Frog  1034 EGDIEQLTDDLIHCLVENLLSIDERESQDSIESINTDT------------------DDEIMNDQD 1080

  Fly   266 EKRAQKTDAEIYVELRAICNSDDPRERYKTT----------------------QEVGKGASGIVF 308
            :|                |.|....|..|:.                      :.:||||.|.|:
Frog  1081 QK----------------CKSPSHNECNKSANTTNIDKLADSSINGSFPWTKGEVLGKGAYGTVY 1129

  Fly   309 IAADLQNE----SQVAVKTID-MKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVV 368
            .....|.|    .||.:.:.| :..|.....:..|:.:||..:|.|:|.:|..  ...::.:.:.
Frog  1130 CGLTSQGELIAAKQVVLDSSDPVTAQKEYKKLQEEVDLLKALDHVNIVGYLGT--CREDNMVTIF 1192

  Fly   369 MEYMDGGPLTDVVTE-TVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTD 432
            ||::.||.:..::.. ..::|.......::.|..|.:||:..:||||||.:|::|..:|.:|:.|
Frog  1193 MEFVPGGSIASILRRFGPLQEMVFIKYTKQILQGIVYLHSNRVIHRDIKGNNLMLMPNGIIKLID 1257

  Fly   433 FGFCA------NIEG--DEKRQTMVGTPY 453
            || ||      |..|  .|..::|.||||
Frog  1258 FG-CAKRLTYLNKSGTQSEMLRSMHGTPY 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	5/26 (19%)
		PKc_like	288..545	CDD:304357	53/202 (26%)
		S_TKc	293..545	CDD:214567	52/197 (26%)
map3k19	XP_002941471.3	ANK repeat	38..68	CDD:293786
		Ank_2	42..128	CDD:403870
		ANK repeat	70..128	CDD:293786
		Ank_2	100..>186	CDD:403870
		ANK repeat	130..174	CDD:293786
		PKc_like	1112..>1285	CDD:419665	49/175 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910