DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and nrk

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_031747384.1	Gene:	nrk / 100486469	XenbaseID:	XB-GENE-952099	Length:	1237	Species:	Xenopus tropicalis

Alignment Length:	287	Identity:	109/287 - (37%)
Similarity:	160/287 - (55%)	Gaps:	23/287 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 YVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRV 341
            |::|.::   .:|...::..:.||.|..|.|:....::.....|:|.:::..:..:::.| ||.:
Frog    12 YIDLASL---REPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTEEEEEEIKL-EINM 72

  Fly   342 LKDF-NHKNLVNFLDAY----LLEPEDQLWVVMEYMDGGPLTDVVTET---VMKERQIACVCRET 398
            ||.: :|:|:..:..|:    |...:||||:||||...|.:||:|.:|   ..||..||.:|||.
Frog    73 LKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREV 137

  Fly   399 LYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVT- 461
            |..::.|||..:||||||..||||..:..||:.|||..|.::.. .:|.|.:||||||||||:.
Frog   138 LRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIAC 202

  Fly   462 ----RKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKS--WDKLSPNLQD 520
                ...|..:.|:||:||.||||.||.||.....|:|||:||..|..|.:||  |.|...|
Frog   203 DENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCIN--- 264

  Fly   521 FLDRCLQVEVDRRATADELLSHPFLND 547
            |:|.||......|.:.|.||.|.|:.|
Frog   265 FVDSCLVKNYSHRPSTDTLLKHAFVRD 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	105/272 (39%)
		S_TKc	293..545	CDD:214567	104/267 (39%)
nrk	XP_031747384.1	STKc_MAP4K4_6_N	8..289	CDD:270806	107/283 (38%)
nrk	XP_031747384.1	CNH	919..1215	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910