DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and nek1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_012827049.2	Gene:	nek1 / 100036653	XenbaseID:	XB-GENE-983162	Length:	1320	Species:	Xenopus tropicalis

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	137/307 - (44%)	Gaps:	55/307 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 RYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDL--ILTEIRVLKDFNHKNLVNFL 354
            :|....::|:|:.|...:.....:..|..:|.|.:...|:|:.  ...|:.||.:..|.|:|.:.
Frog     3 KYVRVSKIGEGSFGKAILVKSKDDGKQYVIKEIGISKMSNKEREESRREVAVLANMKHPNIVQYQ 67

  Fly   355 DAYLLEPEDQLWVVMEYMDGGPLTDVVTE---TVMKERQIACVCRETLYAISFLHAKGIIHRDIK 416
            :::  |....|::||:|.:||.|...:..   .:..|.||.....:...|:..:|.:.|:|||||
Frog    68 ESF--EESGCLYIVMDYCEGGDLFKRINSQKGVLFSEDQILDWFVQLCLALKHVHDRKILHRDIK 130

  Fly   417 SDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIE 480
            |.|:.|...|::::.|||....:... |..:|.:||||:::||:...:.|..|.|||::|.:..|
Frog   131 SQNIFLTKGGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENRPYNNKSDIWALGCVLYE 195

  Fly   481 M-------------------IEGQ-PP----YLYE--TPLRALYLIAANGRPDIKSWDKLSPNLQ 519
            |                   |.|. ||    |.|:  ..|..|:......||.:.|..:     :
Frog   196 MCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSYDLRNLLSMLFKRNPRDRPSVNSILE-----K 255

  Fly   520 DFLDRCLQVEVDRRATADE-----LLSHPFLNDCSEVKALVPNIKAA 561
            .|:.|.::..:..:..|:|     .::||           .|.|:||
Frog   256 PFIYRRIEKFLSPQHIAEEFGLGAFVNHP-----------KPGIQAA 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	74/289 (26%)
		S_TKc	293..545	CDD:214567	74/288 (26%)
nek1	XP_012827049.2	STKc_Nek1	3..258	CDD:270858	68/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910