DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and pak4

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_012823244.1	Gene:	pak4 / 100036644	XenbaseID:	XB-GENE-1013749	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	701	Identity:	213/701 - (30%)
Similarity:	315/701 - (44%)	Gaps:	188/701 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGDGGSIS----------EIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLMNSQITRDEQDKNP 65
            |.|.||::          ||.||.||:...|...:|:.....|||..|..|:      :|..|.|
Frog     7 GHDKGSLATMFGKKKKRIEISAPLNFEHRVHTGFDQQEQKFTGLPRQWQSLI------EESAKRP 65

  Fly    66 ----DAAY-------------------------------HAVKYYNYSIKKKENEVFKPFITEDV 95
                |.:|                               .|:.....:..::|:....|  .||.
Frog    66 KPLVDPSYITTINHVPQKTIVRGSKMSLDGSLAWLLDEFDAMSICRSNSLRRESPPCHP--REDR 128

  Fly    96 IHEESKEIENYVNYK--------------------------------------NKHKSQDP---- 118
            .|:|:...|..|..:                                      |||:...|
Frog   129 FHQENGMSEVRVRQQREDGQRGSERNRSEHSRRERQREEHKAVPQQPRGQEPSNKHRPPPPDYPK 193

  Fly   119 -----------EKSD--------DDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLD-- 162
                       ||.|        |.|.|...|.......|......:|.:..:.|.||  |.|
Frog   194 DIPEKRGTRSHEKGDGRREYPVNDRGYSEPVERVVKREKGEEKRPKSSYTSAEGSPQS--PRDKR 256

  Fly   163 -------------ALEEVFKELKT----NLEHR---ETLKAAPQEPP---PVPPKKSPHTI---- 200
                         :.|.|.|:.:|    |...|   :..:.||.:.|   ...|..|..|:
Frog   257 PLSGPSIRTPGSSSTEGVVKQTQTGRAFNTYPRAETDPSRGAPHQVPDSHSTVPLDSKSTVSKSS 321

  Fly   201 --PPKPQIKP----KPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDNPDET 259
              |.:.|:||    ||..||....:||.:.......||          ||          .|
Frog   322 SRPQQGQVKPKLPDKPHPTQLVPHSSDPQLSHPVQTQH----------PA----------QP--- 363

  Fly   260 ILRRSKEKRAQKTDAEIY-VELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKT 323
               ||.::..|:...|.: ..|:.:.:..|||.......::|:|::|||.||....:...||||.
Frog   364 ---RSPQREPQRVSHEQFRAALQMVVDPGDPRTYLDNFIKIGEGSTGIVCIATIKSSGKLVAVKK 425

  Fly   324 IDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKE 388
            :|::.|..::|:..|:.:::|:.|:|:|...::||:  .|:|||:||:::||.|||:||.|.|.|
Frog   426 MDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLV--GDELWVIMEFLEGGALTDIVTHTRMNE 488

  Fly   389 RQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGD-EKRQTMVGTP 452
            .|||.||...|.|:|.|||:|:||||||||::||..||.||::||||||.:..: .:|:::||||
Frog   489 EQIATVCVSVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVNKEVPRRKSLVGTP 553

  Fly   453 YWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPN 517
            ||||||:::|..||.:|||||:|||.|||::|:|||..|.||:|:.:|..|..|.:|:..|:||.
Frog   554 YWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNAQKVSPL 618

  Fly   518 LQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
            |:.||||.|..:..:||:|:|||.||||........:||       ::|:|
Frog   619 LKGFLDRLLVRDPSQRASANELLKHPFLGKAGPPSCIVP-------LMRQN 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	19/88 (22%)
		PKc_like	288..545	CDD:304357	126/257 (49%)
		S_TKc	293..545	CDD:214567	123/252 (49%)
pak4	XP_012823244.1	CRIB_PAK_like	24..70	CDD:238526	16/51 (31%)
pak4	XP_012823244.1	PKc_like	374..665	CDD:389743	134/298 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920