DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14894 and TOM70

DIOPT Version :9

Sequence 1:	NP_001262636.1	Gene:	CG14894 / 41993	FlyBaseID:	FBgn0038428	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	243	Identity:	69/243 - (28%)
Similarity:	108/243 - (44%)	Gaps:	49/243 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ITEKEATSTRQSEKDVDEIVEKQNQLALDDEAEQGAAGGDSIATPTTVDSELTIEELREREKDLS 83
            |.:.|...|:.|:|:.             :.|::..|..:....|.:.:.          |.|.|
Yeast    44 INKDEKKDTKDSQKET-------------EGAKKSTAPSNPPIYPVSSNG----------EPDFS 85

  Fly    84 PE-QLTANKEKADK----LKVEGNELFKNDDAEGAAKTYTEALDICPSASSKERAVLYGNRAAAK 143
            .: ..||  |:.||    ||.:||:.|:|...:.|.|.|..||::      ||..|.|.|.:|..
Yeast    86 NKANFTA--EEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALEL------KEDPVFYSNLSACY 142

  Fly   144 IKLEANKAAIDDCTKAIELWPEYVRVLLRRAKLYEQEDKPDEALEDYKKVTEIDPGQQEAREAQI 208
            :.:...|..::..|||:||.|:|.:||||||...|...|..:|:.|. .|..::....:|
Yeast   143 VSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDL-SVLSLNGDFNDA----- 201

  Fly   209 RLPPIINERNEKLKNEMMSSLK----DLGNMILKPFGLSTQNFQMQQD 252
            .:.|:: |||  |..:.||.||    |:......|..||||..:.::|
Yeast   202 SIEPML-ERN--LNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKD 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14894	NP_001262636.1	TPR_11	93..164	CDD:290150	25/74 (34%)
		TPR repeat	94..122	CDD:276809	12/31 (39%)
		TPR_11	132..198	CDD:290150	23/65 (35%)
		TPR repeat	132..162	CDD:276809	8/29 (28%)
		TPR_1	133..166	CDD:278916	11/32 (34%)
		TPR	167..198	CDD:197478	11/30 (37%)
		TPR repeat	167..195	CDD:276809	11/27 (41%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	69/243 (28%)
		TPR repeat	99..127	CDD:276809	10/27 (37%)
		TPR repeat	131..161	CDD:276809	8/29 (28%)
		TPR repeat	166..189	CDD:276809	9/22 (41%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.800