Protein Alignment ema and Clec16a

DIOPT Version :9

• Sequence 1: NP_650542.1
• Gene: ema / 41992
• FlyBaseID: FBgn0038427
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_006522723.1
• Gene: Clec16a / 74374
• MGIID: 1921624
• Length: 1052
• Species: Mus musculus
• Alignment Length: 1133
• Identity: 506/1133 - (44%)
• Similarity: 678/1133 - (59%)
• Gaps: 190/1133 - (16%)

  Fly     1 MF-RSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHD 64
            || |||||.||......:|..||:||||||.:|.|||||:|.||.||||::|.|.||||||||:|
Mouse     1 MFGRSRSWVGGGHSKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQND 65

  Fly    65 SLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMV 129
            |.||||||||||..:||:|:|||||  .:||||||||||||||||.:|||||||||||:||||:|
Mouse    66 SSVFDFFLEKNMFVFFLNILRQKSG--RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIV 128

  Fly   130 HKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTI 194
            ||||||||::|.|||.||||||||||.||:|||||||||||.|||||||||||||||||||||||
Mouse   129 HKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTI 193

  Fly   195 SLNVYKV--QNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHL 257
            :||||||  .|.:||.:||||||.|||||||||||.|::|||.||:||.:|::..|||:||||||
Mouse   194 TLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHL 258

  Fly   258 DHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDID 322
            ||||||:|||::..:.||.|||:|||::||:|||::||                     .|.|
Mouse   259 DHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSL---------------------ENPD-- 300

  Fly   323 IQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHS-VFKEGAAEILNSYVEHREVV 386
             :....|::|..|:|:|||.|||::.|||||::||.||||||.| .:.:.|.::..|..:..
Mouse   301 -KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDVPRSSAKPS--- 361

  Fly   387 VPGFGEPDESLEQALD----------------TVTGQSSSSSYALSEDSGVESSSPATTELDSQA 435
            :..|.:|.|:||::|:                ...|:........:||:..::.....||..|::
Mouse   362 IRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGSAEDAQEDAEKTKGTEGGSKS 426

  Fly   436 --DAVEAEQIKL--------------------RNITDEEKQLLQKSSSSTKADFAEMAKPFLDTV 478
              .:.|.|:|::                    :|.|||||      |::|.::.|:.::||||.|
Mouse   427 MKTSGEREEIEMVIMKLGKLSEVAAAGTSVQEQNTTDEEK------SAATNSENAQWSRPFLDMV 485

  Fly   479 LHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFE--QVLAKSTRGAFSYKTALIEHLLNIITQS 541
            .||||..::||.||..|||:||||||:|:..|..:  |:...|.....:|...|.|.|:.|:..:
Mouse   486 YHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSEAEKTTYNHLLAERLIRIMNNA 550

  Fly   542 SQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDL----LFSARNQSMVVIRNFYKSEDI 602
            :||..||||.|:|::..||......||.   |:.   :|:    |..||.:|:.::|:|||.|:|
Mouse   551 AQPDGRIRLATLELSCLLLKQQVLTSSG---CVI---KDVHLACLEGAREESVHLVRHFYKGEEI 609

  Fly   603 FLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLR 667
            |||:|||||..|....:|||:|.||::|||||||||||||:|.:|||||:|||.||||||:|:||
Mouse   610 FLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLR 674

  Fly   668 RTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEP 732
            ....:...|.|:.||||...:|::.::||||||||||||||:.||....:|||.:|..|:.||||
Mouse   675 SLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEP 739

  Fly   733 DAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHR-GGVTHNRT-PLLSAKFLFDDHIRCMAA 795
            |...|||||.||.|.|||::|.|.:||||.|:||:|: ....|::. |:|.|.|:|.|||||:.|
Mouse   740 DVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIA 804

  Fly   796 KQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSGGS-------------GNSS 847
            ||||.|||.:||:.||.:||.|:::|.|   |...|.|..:.|||..|             |:|.
Mouse   805 KQRLAKGRIQARRMKMQRIAALLDLPIQ---PTTEVLGFGLCSSSSSSQHLPFRFYEQCRRGSSD 866

  Fly   848 GSSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTS 912
            .:..||     :|::.::|||||..                    :.|...|:......||...|
Mouse   867 PTVQRS-----VFASVDKVPGFAVA--------------------QCINQHSSPSLSSPSPPFAS 906

  Fly   913 GS---NLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPRSEEIPL----- 969
            ||   :....|.|       |.||.|:..:.::.....|       :|..|:|..::..:
Mouse   907 GSPGGSGSTSHCD-------SGGSSSAPSATQSPADAPT-------TPEQPQPHLDQSVIGNEMD 957

  Fly   970 EDFQHSRNNSPHSRG------NPSPASRSHTPIRVLHYD--------------QLSGHSGSPREA 1014
            .:.:.|:|:|..|..      :||........|.:|:.|              .:..||
Mouse   958 VNSKPSKNSSARSSEGETMHLSPSLLPAQQPTISLLYEDTADTLSVESLTIVPPVDPHS------ 1016

  Fly  1015 SLGGTNALLSQLNGLNREVLPTQSSEET 1042
                    |..|:|:::  |||..:.:|
Mouse  1017 --------LRALSGISQ--LPTLPAADT 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ema	NP_650542.1	FPL	50..199	CDD:313053	122/148 (82%)
Clec16a	XP_006522723.1	FPL	51..198	CDD:370666	122/148 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831203
Domainoid	1	1.000	533	1.000	Domainoid score	I282
eggNOG	1	0.900	-	-		E1_KOG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71019
Inparanoid	1	1.050	835	1.000	Inparanoid score	I451
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52345
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006421
OrthoInspector	1	1.000	-	-		oto95429
orthoMCL	1	0.900	-	-		OOG6_103636
Panther	1	1.100	-	-	LDO	PTHR21481
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5071
SonicParanoid	1	1.000	-	-		X4687
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790