DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ema and Clec16a

DIOPT Version :9

Sequence 1:	NP_650542.1	Gene:	ema / 41992	FlyBaseID:	FBgn0038427	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_008765727.1	Gene:	Clec16a / 287044	RGDID:	1305773	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	1146	Identity:	507/1146 - (44%)
Similarity:	679/1146 - (59%)	Gaps:	186/1146 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-RSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHD 64
            || |||||.||..|...:|..||:||||||.:|.|||||:|.||.||||::|.|.||||||||:|
  Rat     1 MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQND 65

  Fly    65 SLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMV 129
            |.||||||||||..:||:|:|||||  .:||||||||||||||||.:|||||||||||:||||:|
  Rat    66 SSVFDFFLEKNMFVFFLNILRQKSG--RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIV 128

  Fly   130 HKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTI 194
            ||||||||::|.|||.||||||||||.||:|||||||||||.|||||||||||||||||||||||
  Rat   129 HKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTI 193

  Fly   195 SLNVYKV--QNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHL 257
            :||||||  .|.:||.:||||||.|||||||||||.|::|||.||:||.:|::..|||:||||||
  Rat   194 TLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHL 258

  Fly   258 DHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDID 322
            ||||||:|||::..:.||.|||:|||::||:|||:.||                     .|.|
  Rat   259 DHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVHSL---------------------ENPD-- 300

  Fly   323 IQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHS-VFKEGAAEILNSYVEHREVV 386
             :....|::|..|:|:|||.|||::.|||||::||.||||||.| .:.:.|.:...|..:..
  Rat   301 -KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDAPRSSAKPS--- 361

  Fly   387 VPGFGEPDESLEQALD----------------TVTGQSSSSSYALSEDSGVESSSPATTELDSQA 435
            :..|.:|.|:||::|:                ...|:........:||:..::.....||..|::
  Rat   362 IRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGSAEDAQEDAEKTKGTEGGSKS 426

  Fly   436 --DAVEAEQIKL--------------------RNITDEEKQLLQKSSSSTKADFAEMAKPFLDTV 478
              .:.|.|:|::                    :|.|||||      |::|.::.|:.::||||.|
  Rat   427 MKTSGEREEIEMVIMKLGKLSEVATAGASVQEQNTTDEEK------SAATSSENAQWSRPFLDMV 485

  Fly   479 LHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFE--QVLAKSTRGAFSYKTALIEHLLNIITQS 541
            .||||..::||.||..|||:||||||:|:..|..:  |:...|.....:|...|.|.|:.|:..:
  Rat   486 YHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSEAEKTTYNHLLAERLIRIMNNA 550

  Fly   542 SQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDL----LFSARNQSMVVIRNFYKSEDI 602
            :||..||||.|:|::..||......||.   |:.   :|:    |..||.:|:.::|:|||.|:|
  Rat   551 AQPDGRIRLATLELSCLLLKQQVLTSSG---CVI---KDVHLACLEGAREESVHLVRHFYKGEEI 609

  Fly   603 FLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLR 667
            |||:|||||..|....:|||:|.||::|||||||||||||:|.:|||||:|||.||||||:|:||
  Rat   610 FLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLR 674

  Fly   668 RTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEP 732
            ....:...|.|:.||||...:|::.::||||||||||||||:.||....:|||.:|..|:.||||
  Rat   675 SLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEP 739

  Fly   733 DAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHR-GGVTHNRT-PLLSAKFLFDDHIRCMAA 795
            |...|||||.||.|.|||::|.|.:||||.|:||:|: ....|::. |:|.|.|:|.|||||:.|
  Rat   740 DVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIA 804

  Fly   796 KQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSG----------GSGNSSGSS 850
            ||||.|||.:||:.||.:||.|:::|.|..:.|...|  :.::||.          ..|:|..:.
  Rat   805 KQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFG--LCSTSSQHLPFRFYEQCRRGSSDPTV 867

  Fly   851 SRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSGS- 914
            .||     :|::.::|||||..                    :.|...|:......||...|||
  Rat   868 QRS-----VFASVDKVPGFAVA--------------------QCINQHSSPSLSSPSPPFASGSP 907

  Fly   915 --NLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPR------SEEIPLED 971
              :....|.|       |.||.|:..:.::.....|       :|..|:|.      ..|:.:..
  Rat   908 GGSGSTSHCD-------SGGSSSAPSATQSPADAPT-------TPEQPQPHLDQSVIGNEVDVNS 958

  Fly   972 FQHSRNNSPHSRG------NPSPASRSHTPIRVLHYD--------------QLSGHSGSPREASL 1016
             :.|:|:|..|..      :||........|.:|:.|              .:..||
  Rat   959 -KPSKNSSARSSEGETMHLSPSLLPAQQPTISLLYEDTADTLSVESLTLVPPVDPHS-------- 1014

  Fly  1017 GGTNALLSQLNGLNREVLPTQSSEETSFIGSDGNEATGGSE 1057
                  |..|:|:::......:..||...|:...|..|.:|
  Rat  1015 ------LRALSGISQLPAMAAADSETPAEGAVSPEPAGPTE 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ema	NP_650542.1	FPL	50..199	CDD:313053	122/148 (82%)
Clec16a	XP_008765727.1	FPL	51..198	CDD:286801	122/148 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334927
Domainoid	1	1.000	529	1.000	Domainoid score	I278
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71019
Inparanoid	1	1.050	837	1.000	Inparanoid score	I425
OMA	1	1.010	-	-		QHG52345
OrthoDB	1	1.010	-	-		D1319544at2759
OrthoFinder	1	1.000	-	-		FOG0006421
OrthoInspector	1	1.000	-	-		oto98915
orthoMCL	1	0.900	-	-		OOG6_103636
Panther	1	1.100	-	-	LDO	PTHR21481
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4687
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910