DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ema and CLEC16A

DIOPT Version :9

Sequence 1:	NP_650542.1	Gene:	ema / 41992	FlyBaseID:	FBgn0038427	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_056041.1	Gene:	CLEC16A / 23274	HGNCID:	29013	Length:	1053	Species:	Homo sapiens

Alignment Length:	1068	Identity:	497/1068 - (46%)
Similarity:	665/1068 - (62%)	Gaps:	152/1068 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF-RSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHD 64
            || |||||.||..|...:|..||:||||||.:|.|||||:|.||.||||::|.|.||||||||:|
Human     1 MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQND 65

  Fly    65 SLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMV 129
            |.||||||||||..:||:|:|||||  .:||||||||||||||||.:|||||||||||:||||:|
Human    66 SSVFDFFLEKNMFVFFLNILRQKSG--RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIV 128

  Fly   130 HKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTI 194
            ||||||||::|.|||.||||||||||.||:|||||||||||.|||||||||||||||||||||||
Human   129 HKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTI 193

  Fly   195 SLNVYKV--QNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHL 257
            :||||||  .|.:||.:||||||.|||||||||||.|::|||.||:||.:|::..|||:||||||
Human   194 TLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHL 258

  Fly   258 DHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDID 322
            ||||||:|||::..:.||.|||:|||::||:|||::||                     .|.|
Human   259 DHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSL---------------------ENQD-- 300

  Fly   323 IQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHS-VFKEGAAEILNSYVEHREVV 386
             :....|::|..|:|:|||.|||::.|||||::||.||||||.| ::.:...:|..|..:..
Human   301 -KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPS--- 361

  Fly   387 VPGFGEPDESLEQALD----------------TVTGQSSSSSYALSEDSGVESSSPATTELDSQA 435
            :..|.:|.|:||::|:                ...|:........:||:..::.....||..|:.
Human   362 IRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKG 426

  Fly   436 --DAVEAEQIKL-------------------RNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVL 479
              .:.|:|:|::                   :|.||||     ||:::|.::..:.::||||.|.
Human   427 IKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEE-----KSAAATCSESTQWSRPFLDMVY 486

  Fly   480 HALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQV------LAKSTRGAFSYKTALIEHLLNII 538
            ||||..::||.||..|||:||||||:|:..|..|::      .|:.|    :|...|.|.|:.|:
Human   487 HALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKT----TYNHPLAERLIRIM 547

  Fly   539 TQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDL----LFSARNQSMVVIRNFYKS 599
            ..::||..:|||.|:|::..||......|:.   ||   .:|:    |..||.:|:.::|:|||.
Human   548 NNAAQPDGKIRLATLELSCLLLKQQVLMSAG---CI---MKDVHLACLEGAREESVHLVRHFYKG 606

  Fly   600 EDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYF 664
            ||||||:|||||..|....:|||:|.||::|||||||||||||:|.:|||||:|||.||||||:|
Human   607 EDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFF 671

  Fly   665 LLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLIL 729
            :||....:...|.|:.||||...:|::.::||||||||||||||:.||....:|||.:|..|:.|
Human   672 MLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSL 736

  Fly   730 VEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHR-GGVTHNRT-PLLSAKFLFDDHIRC 792
            ||||...|||||.||.|.|||::|.|.:||||.|:||:|: ....|::. |:|.|.|:|.|||||
Human   737 VEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRC 801

  Fly   793 MAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVG-GTMVAS--------SSGGSGNSSG 848
            :.|||||.|||.:||:.||.:||.|:::|.|..:.|...| |:..::        ..|..|:|..
Human   802 IIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDP 866

  Fly   849 SSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSG 913
            :..||     :|::.::|||||..                    :.|...|:.....:||.|.||
Human   867 TVQRS-----VFASVDKVPGFAVA--------------------QCINQHSSPSLSSQSPPSASG 906

  Fly   914 SNLRADHSDRERSPSVS-MGSHSSSQSRENSQPRSTGNRSRES--SPRMPRPR-SEEIPL----- 969
                        |||.| ..||..|....:|...||.....::  ||.:|:|. .:::.:
Human   907 ------------SPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETE 959

  Fly   970 EDFQHSRNNSPHSRGNPSPASRSHTPIR 997
            .|.:.|:|.:..:....:..|.|..|.|
Human   960 ADSKPSKNVARSAAVETASLSPSLVPAR 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ema	NP_650542.1	FPL	50..199	CDD:313053	122/148 (82%)
CLEC16A	NP_056041.1	FPL	51..198	CDD:286801	122/148 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..434		8/58 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..471		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..983		24/102 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141261
Domainoid	1	1.000	525	1.000	Domainoid score	I293
eggNOG	1	0.900	-	-		E1_KOG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71019
Inparanoid	1	1.050	832	1.000	Inparanoid score	I458
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52345
OrthoDB	1	1.010	-	-		D1319544at2759
OrthoFinder	1	1.000	-	-		FOG0006421
OrthoInspector	1	1.000	-	-		oto91851
orthoMCL	1	0.900	-	-		OOG6_103636
Panther	1	1.100	-	-	LDO	PTHR21481
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5071
SonicParanoid	1	1.000	-	-		X4687
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800