DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14881 and Hsd17b4

DIOPT Version :9

Sequence 1:	NP_732137.1	Gene:	CG14881 / 41990	FlyBaseID:	FBgn0038425	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_032318.2	Gene:	Hsd17b4 / 15488	MGIID:	105089	Length:	735	Species:	Mus musculus

Alignment Length:	189	Identity:	37/189 - (19%)
Similarity:	68/189 - (35%)	Gaps:	64/189 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VLHSLALFYQLLEFGERTERDLLLSPAVLRTVQEWRVKAHDERILSSKAVK-------------Q 171
            :||.|..|    .|..|            ..:|::.    |..:...||:|             |
Mouse   529 ILHGLCTF----GFSAR------------HVLQQFA----DNDVSRFKAIKVRFAKPVYPGQTLQ 573

  Fly   172 VQVVKRFSQSDLEQFAQFTGD----HNYIH-------SLETPTEERRVHGALLNAVVAGIMGTQL 225
            .::.|..::...:.....|||    :.|:.       |.:||:|    .|.|.:|:|.|.:|.:|
Mouse   574 TEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPASGVSTQTPSE----GGELQSALVFGEIGRRL 634

  Fly   226 PGPGTVVLEQNFKFLKPCRIETDTVVTVRLLQSRKIS---TVEYDIRQNDEVVFAGSAK 281
            ...|..|::           :.:.|....:.:...::   |:  |::.....|:.|.||
Mouse   635 KSVGREVVK-----------KANAVFEWHITKGGTVAAKWTI--DLKSGSGEVYQGPAK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14881	NP_732137.1	R_hydratase	171..283	CDD:239533	26/125 (21%)
Hsd17b4	NP_032318.2	(3R)-hydroxyacyl-CoA dehydrogenase	1..305
		hydroxyacyl-CoA-like_DH_SDR_c-like	5..254	CDD:187611
		fabG	6..226	CDD:235546
		Enoyl-CoA hydratase 2	321..621		22/115 (19%)
		PLN02864	329..604	CDD:178455	17/94 (18%)
		hot_dog	<394..443	CDD:294345
		(3R)-3-hydroxydecanoyl-CoA binding. /evidence=ECO:0000250	405..406
		HDE_HSD	484..604	CDD:239532	17/94 (18%)
		(3R)-3-hydroxydecanoyl-CoA binding. /evidence=ECO:0000250	509..514
		SCP2	633..730	CDD:280250	10/61 (16%)
		Microbody targeting signal. /evidence=ECO:0000255	733..735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810