DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17565 and FNTB

DIOPT Version :9

Sequence 1:	NP_650540.1	Gene:	CG17565 / 41989	FlyBaseID:	FBgn0038424	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_002019.1	Gene:	FNTB / 2342	HGNCID:	3785	Length:	437	Species:	Homo sapiens

Alignment Length:	404	Identity:	208/404 - (51%)
Similarity:	257/404 - (63%)	Gaps:	22/404 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DEKVSTTTSREQQKTESSVEKCFD--RFEQIMFTDPRLTQIFRLEHQYYLDAMLRRLPSNYECLD 84
            |:.|.|.||.||.|.|..:::.|.  :|..::   |||. :.|.:|.:||...||:|...|||||
Human    37 DDSVETVTSIEQAKVEEKIQEVFSSYKFNHLV---PRLV-LQREKHFHYLKRGLRQLTDAYECLD 97

  Fly    85 SSRAWCVYWILQAAQLLSFNFDDQTLNHVVQFLSNCRSPTGGFGGGPGQYAHLAPTYAAVNSLCI 149
            :||.|..||||.:.:||...........|.|||..|:||.||||||||||.||||||||||:|||
Human    98 ASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCI 162

  Fly   150 IGSEQAYRAIDRPTLVQFLFSVRDSDGSFRLHVDGETDVRGAYCAISCAKLLNLPEPVIKELFAG 214
            ||:|:||..|:|..|:|:|:|::..||||.:||.||.|||.||||.|.|.|.|:..|   :||.|
Human   163 IGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITP---DLFEG 224

  Fly   215 TGDWIAQCQTYEGGFGGAPGLEAHGGYTFCGIAGLALLNEADKCDRQALLKWTLRRQMTYEGGFQ 279
            |.:|||:||.:|||.||.||:||||||||||:|.|.:|......:.::||:|...|||.:|||||
Human   225 TAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQ 289

  Fly   280 GRTNKLVDGCYSFWVGATIPITQATLSGVDK---QMEHTLFDVEALQEYILLCCQKQSGGLIDKP 341
            ||.|||||||||||....:|:....|.....   .|.|.:|..:|||||||:|||..:|||:|||
Human   290 GRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKP 354

  Fly   342 GKPQDLYHTCYTLSGVSIAQH--SECASSPQVLGDTINELLPTHPLFNIPPKSVAAARSHFSNSN 404
            ||.:|.|||||.|||:|||||  |.......|||...|.|.||||::||.|..|..|
Human   355 GKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQA-------- 411

  Fly   405 DTEFLGKDSPSKEE 418
            .|.||.|..|..||
Human   412 TTYFLQKPVPGFEE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17565	NP_650540.1	PLN02710	27..403	CDD:215380	199/382 (52%)
CG17565	NP_650540.1	FTase	62..360	CDD:239223	168/300 (56%)
FNTB	NP_002019.1	FTase	75..373	CDD:239223	168/300 (56%)
		PFTB 1	123..164		30/40 (75%)
		PFTB 2	174..215		23/40 (58%)
		PFTB 3	222..263		27/40 (68%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	248..251		2/2 (100%)
		PFTB 4	270..312		25/41 (61%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	291..294		1/2 (50%)
		Farnesyl diphosphate binding. /evidence=ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176	300..303		2/2 (100%)
		PFTB 5	332..374		29/41 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141012
Domainoid	1	1.000	63	1.000	Domainoid score	I10293
eggNOG	1	0.900	-	-		E1_COG5029
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1535
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1948
Isobase	1	0.950	-	0	Normalized mean entropy	S1245
OMA	1	1.010	-	-		QHG54572
OrthoDB	1	1.010	-	-		D1042804at2759
OrthoFinder	1	1.000	-	-		FOG0004877
OrthoInspector	1	1.000	-	-		oto90911
orthoMCL	1	0.900	-	-		OOG6_101706
Panther	1	1.100	-	-	LDO	PTHR11774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2119
SonicParanoid	1	1.000	-	-		X3440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750