Protein Alignment ss and hif1aa

DIOPT Version :10

• Sequence 1: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Sequence 2: NP_001295488.1
• Gene: hif1aa / 797150
• ZFINID: ZDB-GENE-080917-55
• Length: 717
• Species: Danio rerio
• Alignment Length: 1009
• Identity: 198/1009 - (19%)
• Similarity: 338/1009 - (33%)
• Gaps: 386/1009 - (38%)

  Fly    23 PPKDGVTKSNPSKRHRE----RLNAELDLLASL---LPFEQNILSKLDRLSILRLSVSYLRTKSY 80
            |.|..|:.....::.|:    |...|.::...|   ||...::.|.||:.|::||::||||.:..
Zfish     6 PGKKRVSSERRKEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKL 70

  Fly    81 FQV-VMHK----DKEDNGVLPHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMILTCEGEVF 140
            ... |:.|    |.:.||                           .||:||:|||::|:.:|::.
Zfish    71 LNSDVLEKETALDTQWNG---------------------------SFLKALDGFLLVLSADGDIV 108

  Fly   141 FATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLWNSFLPADMSSMQLAETLAPDKALYL 205
            :.:.::...||..|.::...||:|..|..|.||| |::|.:.|..:..|..|           ..
Zfish   109 YLSENVSKCLGLPQIELTGHSVFEFTHPCDHEEL-REMLAHRFGLSKKSKDQ-----------NT 161

  Fly   206 ERSFTVRFRCLLDN--------TSGFLRLDIRGRIKVLHGQNRKTEEPPLALFAY----CTPFGP 258
            .|||.:|.:|.|.:        ::.:..|...|||....|..::..|.......|    |.....
Zfish   162 NRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGRIHTADGVEKEVCEEKNTCSTYLVLICESIPH 226

  Fly   259 PSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGGYDLVHYDDLAYVASAHQEL 323
            |:.:|.|.....|.|:|.||......|:|...:||:...:::....|:..|..|..::...|..|
Zfish   227 PANIEAPLDSRTFLSRHTLDMRFTYCDERITELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSL 291

  Fly   324 LKTGASGMIAYRYQKKDGEWQWLQTSSRLVY--KNSKPDFVICTHRQLMDEEGHDLLGKRTMDFK 386
            ...|......||...|.|.:.|.:|.:.::|  |||:...|:|
Zfish   292 FVKGQVCTGQYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVC---------------------- 334

  Fly   387 VSYLDTGLASTYFSEADQLVVPPSTSPT-----AHALPPPVTPTRPNRRYKTQLRDFLSTCRSKR 446
            |:|:.:|:     .:..|::....|:.|     .|.....||        ..:|::      .::
Zfish   335 VNYILSGI-----EQPKQILSLQQTNSTKIKQEEHQEEVEVT--------MAELKE------EEK 380

  Fly   447 KLQQQN----QPQTQQTSPLGGQ-----VGSPAPAVAVEYLPDPAAAVAAAYSNLNPMYTTSPYA 502
            ::.:::    ||..|..| |.|:     |..|...:.:. :.|.|.:|....    |:|
Zfish   381 EMDKEDEECVQPVVQHNS-LKGETEALTVADPVLTLDIN-ITDSAISVLTEI----PLY------ 433

  Fly   503 SAADNLYMGSS---MPANAFYPVSENLFHQYRLQGAVGGYYTDYPHSGAPASAY----VANGFLS 560
               :::.:.||   :|.:...|                           |.|:.    .:.|.|.
Zfish   434 ---NDVMLPSSDVLLPLSPLSP---------------------------PCSSLNDDEASTGHLQ 468

  Fly   561 YDGYAIASKADEKWQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVG- 624
            :|.:.....:|                     |:..|:.|      |...|:  |....|..|.
Zfish   469 HDQFPFQQSSD---------------------SSRSQVDL------PVDSEL--CDQLKPDHVEK 504

  Fly   625 ------GATPNGVG----SVTPKVELAGTTAAAAAGQDPYERQTVLMWGTTHSSGVPLNSHGGRT 679
                  .:...|||    .:.|.:.:          .|.::.:||
Zfish   505 HFSMDIESKTQGVGLDLEMLAPYIPM----------DDDFQLRTV-------------------- 539

  Fly   680 GAGNPASPQRSTPLGNGLGYASANNNNNDLEPATAAKWNGTKELPGKSGSASTPESYQMQHDDSG 744
               :|..|..|:|. :||          ||.|:::     |:..|..  ||:||:|.
Zfish   540 ---SPVRPMCSSPC-SGL----------DLTPSSS-----TQTSPAL--SAATPDSL-------- 575

  Fly   745 LYSASSHTTSPQQQQQQQLQQSQRGVGSNVSAPSSSLTSTGTDQQAVHPSSCHQQQQQQQQQHHH 809
                                                              ||...||:.:
Zfish   576 --------------------------------------------------SCDPVQQKNK----- 585

  Fly   810 AHPHPHSHHHHHHHHHHETAHQHSSEII----LTTHHQQQSQQQQQSLAGYPLHHQLVGVGS--- 867
                             .|...||.|||    ::...|...:..::.|...|| .:.:.:||
Zfish   586 -----------------TTVQDHSREIIQDSDISYKCQTNPKLLKRKLETIPL-SEAIRLGSVLQ 632

  Fly   868 -GSPPPQPPVALSRSPTT----------LPA-VSSLLNGSASAGGASDIPYQQL----AIVSAPL 916
             .:..|:..|..:.:|::          ||: |:|.|...:|.|||..:|..|:    ..|:||:
Zfish   633 VVTDFPEKKVRKTDAPSSEGIRHATILLLPSNVASRLLSRSSEGGAIAMPLPQITHHDCEVNAPV 697

  Fly   917 VICAEEVGGGVSSIGRKSSKQQQSLQHLQQQQSL 950
                         |||         |||.|.:.|
Zfish   698 -------------IGR---------QHLLQGEEL 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	19/70 (27%)
		PAS	123..178	CDD:214512	20/54 (37%)
		PAS_3	282..366	CDD:430001	22/85 (26%)
hif1aa	NP_001295488.1	bHLH_SF	11..79	CDD:469605	18/67 (27%)
		PAS	85..150	CDD:214512	24/92 (26%)
		PAS	236..335	CDD:238075	27/120 (23%)
		HIF-1	<519..541	CDD:463274	4/54 (7%)
		HIF-1a_CTAD	683..716	CDD:430212	12/49 (24%)